Results 91 to 100 of about 837,527 (297)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

The Analysis of Force Parameters in Drawing Process of High Carbon Steel Wires in Conventional and Hydrodynamic Dies

open access: yesArchives of Metallurgy and Materials, 2017
The paper analyzes force parameters in the process of multistage drawing of steel wires in conventional and hydrodynamic dies. The drawing process of the wire rod with a diameter of 5.5 mm for wires with a diameter of 1.70 mm was performed in 12 drafts ...
Suliga M.
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

Projekt for manufacturing of gears for Company Stab spol. s r. o. [PDF]

open access: yes, 2020
Diplomová práca opisuje projekt na založenie novej divízie pre firmu ktorá sa zaoberá generálnymi opravami strojov. V prvej časti práce je rozoberaná teoretická časť o výrobnom procese ozubenia a ekonomická časť tejto práce. Hlávne časti práce sú analýza
Štefan Staník
core  

A conceptual design tool: Sketch and fuzzy logic based system [PDF]

open access: yes, 2001
A real time sketch and fuzzy logic based prototype system for conceptual design has been developed. This system comprises four phases. In the first one, the system accepts the input of on-line free-hand sketches, and segments them into meaningful parts ...
Jordanov, IN, Qin, SF, Wright, DK
core  

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz   +25 more
wiley   +1 more source

Effect of temperature and drawing speed on warm deep drawing characteristics of AZ31 magnesium alloy sheet

open access: yesJournal of Japan Institute of Light Metals, 2006
In this study, effect of drawing speed and flange temperature on formability of cylindrical cup warm deep drawing of AZ31 magnesium alloy sheet is clarified experimentally. For the purpose, a new locally heating and cooling deep drawing apparatus is designed and developed. Magnesium alloy used is AZ31 sheet with 0.5mm thickness.
Ken-ichi MANABE, Osamu SHIMOMURA
openaire   +2 more sources

RC rate generator for slow speed measurement Patent [PDF]

open access: yes, 1968
Device utilizing RC rate generators for continuous slow speed ...
Loyd, C., Mccampbell, W. M.
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin   +11 more
wiley   +1 more source

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