Results 121 to 130 of about 1,115,153 (282)

Design of Monitoring Systems for Contaminant Detection in Water Networks Under Pipe Break-Induced Events

open access: yesSensors
Water distribution networks (WDNs) are critical infrastructure yet vulnerable to contamination, thereby threatening public health. Rapid contaminant detection through sensor systems is essential for water safety.
Ludovica Palma   +3 more
doaj   +1 more source

H2S paper strip method - A bacteriological test for faecal coliforms in drinking water at various temperatures [PDF]

open access: yes, 1998
Epidemics arising from waterborne diseases are a global health problem. Faecal contamination of drinking water is the main cause of these outbreaks. According to WHO (1996) for drinking water to be safe, a 100 ml sample should not contain any coliform ...
Gibbs, R.   +3 more
core   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

open access: yesAdvanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma   +10 more
wiley   +1 more source

Detection of Complex Formations in an Inland Lake from Sentinel-2 Images Using Atmospheric Corrections and a Fully Connected Deep Neural Network

open access: yesRemote Sensing
The detection of complex formations, initially suspected to be oil spills, is investigated using atmospherically corrected multispectral satellite images and deep learning techniques.
Damianos F. Mantsis   +7 more
doaj   +1 more source

Metering gun for dispensing precisely measured charges of fluid [PDF]

open access: yes, 1974
A cyclically operable fluid dispenser for use in dispensing precisely measured charges of potable water aboard spacecraft is described. The dispenser is characterized by (1) a sealed housing adapted to be held within a crewman's palm and coupled with a ...
Cook, T. A., Scheibe, H.
core   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

open access: yesAdvanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang   +11 more
wiley   +1 more source

Vulnerability assessment of hydrological ecosystem services under future climate and land use change dynamics

open access: yesEcological Indicators
Hydrological Ecosystem Services (HESs), as an important part of ecosystem services, are those services that depend on hydrological processes. HESs vulnerability assessment at the watershed scale is used to explore highly vulnerable areas for management ...
Negar Tayebzadeh Moghadam   +2 more
doaj   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

open access: yesAdvanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao   +8 more
wiley   +1 more source

DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy

open access: yesAdvanced Science, EarlyView.
Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi   +12 more
wiley   +1 more source

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