Results 231 to 240 of about 958,985 (302)

Head Scanning by Drivers With Left Homonymous Visual Field Loss: A Naturalistic Driving Pilot Study. [PDF]

open access: yesAm J Occup Ther
Choe S   +6 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Drivers and potential mitigation solutions for low-value medical imaging in Iran: a qualitative study. [PDF]

open access: yesBMJ Open
Darban Hosseini Amirkhiz G   +8 more
europepmc   +1 more source

Visual field assessment and driving licence eligibility in India: A hospital-based cross-sectional study. [PDF]

open access: yesIndian J Ophthalmol
Singh M   +6 more
europepmc   +1 more source

Pandemic risk in the Shared Socioeconomic Pathways

open access: yes
Lavelle TE   +13 more
europepmc   +1 more source

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