Results 141 to 150 of about 1,796,768 (309)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
A smart driving smartphone application : real-world effects on driving performance and glance behaviours [PDF]
A smart driving Smartphone application – which offers real-time fuel efficiency and safety feedback to the driver in the vehicle – was evaluated in a real-world driving study.
Fowkes, Mark +2 more
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Stability and change in risky driving from the late teens to the late twenties [PDF]
, 2013 This paper examines patterns of risky driving from the late teens to the late twenties and identifies factors associated with persistence and change in risky driving tendencies.Key findings: Rates of risky driving remained fairly stable between the ...
Suzanne Vassallo +2 more
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
An Examination of the Effects of Videophones on Driving and Conversation Performance [PDF]
, 2011 Research has conclusively shown that cell phones have a detrimental effect on driving performance. In an attempt to understand why, a handful of researchers have investigated the differences between cell phone and passenger conversations, with several of
Mackenzie, Kathryn Julie
core
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Findings from the DUMA program: drink and drug driving among police detainees [PDF]
, 2015 This paper finds that detainees do perceive a risk related to drink and drug driving, in terms of impairment in driving ability and potential detection by police.
Susan Goldsmid +2 more
core