Results 131 to 140 of about 1,796,768 (309)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Optimal Drunk Driving Penalty Structure [PDF]
The expected penalty for drunk driving can and does vary by blood alcohol content. This paper outlines the "penalty structure" that does this optimally, using two different metrics, shows how the optimality conditions can be implemented with available ...
Darren Grant
core
Influence of driving style on fuel consumption and Emissions in diesel-powered passenger car [PDF]
, 2010 This paper presents the main results of a study on the influence of driving style on fuel consumption and pollutant emissions of diesel passenger car in urban traffic.
Casanova Kindelán, Jesús +2 more
core
Michi‑Drive (U‑Drive) as the Base Drive of Life
This work introduces the Michi‑Drive (U‑Drive), a structural and implementation‑agnosticinformation‑gradient model that defines the fundamental dynamical force driving livingsystems toward the unknown. It formalizes the known/unknown distinction, the BaseDrive,and the algorithmic structure of exploration without relying on psychological constructssuch ...
openaire +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshuWe have repeatedly considered Holographic Neural Network (HNN) emerged by Sutherland ,J. G. as a causable machine learning. As a result, we developed FQHNN (Fuzzy Quantification Theory Embedded Holographic Neural Network) which has been already applied ...
Hiroe ABE +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Oregon impaired driving strategic plan
, 2018 presented by the Oregon Governor's Advisory Committee on Driving Under the Influence of Intoxicants.Title from PDF cover (viewed on May 27, 2021).Covers OCLC #1261027025, OCLC #1252919733 and OCLC #1091192431.This archived document is maintained by the ...
core
What is difficult at intersections? Virtual and real driving [PDF]
, 2006 One important source of drivers’ errors is a high level of stress which may hinder the perception and processing of relevant information. In a real-driving study the visibility within the traffic situation was shown to be a major factor increasing stress.
Vollrath, Mark, Rataj, Jürgen
core