Results 111 to 120 of about 1,796,768 (309)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
By-laws and charter of the Temple Driving Park and Fair Association
, 1892 Pamphlet containing the bylaws and charter for the Temple Driving Park and Fair Association.'The purposes of this association are to maintain a driving park and public fairs and exhibitions of stock and manufactured products, and encouragement of ...
Temple Driving Park and Fair Association (Temple, Tex.)
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Road Fatality Model Based on Over-Dispersion Data Along Federal Route F0050
MATEC Web of Conferences, 2017 According to The World Health Ranking 2011 has ranked Malaysia as 20th in its list of countries with the most deaths caused by road accidents. Road accidents also have been identified as the prime cause of death in Malaysia after the heart disease ...
Musa Wan Zahidah +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Enhanced game mode for Eco-driving simulator [PDF]
, 2012 The use of driving simulators is part of RENAULT’s approach for eco-driving development. The geDRIVER project objectives were to: develop ECO mode for all, taking into account eco-driving criteria; develop a training business offer and develop specific ...
KEMENY, Andras +6 more
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, 2011 This book section is from Auto motives : understanding car use behaviours: Our global reliance on private automobiles as the primary means for transporting individuals is likely to become of increasing political importance over the next ten to twenty years.
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2014 While there is a lot of work around drink-driving, it generally focuses on young men and the risk they pose to themselves and to others. There is no doubt that young men are the most concerning demographic. However, with the on-going ...
Jenny Neale, Greg Martin
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