Results 61 to 70 of about 3,045,870 (300)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
World Electric Vehicle JournalStandardized driving cycles often inadequately represent the driving patterns specific to a particular city, and variations in vehicle types within the same city further contribute to discrepancies in driving cycles.
Rui Liang, Junnan He, Pei Lu
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
VehiclesConstructing the driving cycle of pure electric passenger vehicles (PEPVs) can provide a comprehensive understanding of the operational characteristics, thereby offering fundamental support for the continuous improvement of their performance.
Xiaopeng Huang +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
, 2021 Wheeled mobile driving simulators (WMDS) intend to cue the motion of road vehicles by moving a tire-bound, electrically driven, omnidirectional platform.
Albrecht, Torben +9 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Novel k-MPSO Clustering Algorithm for the Construction of Typical Driving Cycles
IEEE Access, 2020 The practical driving cycle is of great significance in studying the control strategy of vehicles, and effective clustering of micro-trips is the key to obtaining the typical driving cycle.
Wei Yan +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Driving Data Analysis for the Development of Kuala Terengganu Driving Cycle
, 2023 Driving cycle plays a vital role in the production and evaluating the performance of the vehicle. Driving cycle is a speed-time data set and as an important input for vehicle emission models.
Walker, P +4 more
core +1 more source