Results 121 to 130 of about 1,723,395 (300)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Constructing Emission-Intensive Driving Cycles for an Extended-Range Electric Vehicle via Dynamic Programming Guided by Real-World Trip Dynamics and Road Terrain

Applied Sciences
Reproducing severe emission driving scenarios on a chassis dynamometer enables the systematic calibration of real driving emissions (RDE) under laboratory conditions.
Yang Chen, Hualong Xu, Li Zhang, Qing Zhang, Chengzhi Jian   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The ecology of urban driving II--driving cycles across a city: Their validation and implications

Homogeneous urban areas defined through an urban ecology approach are used to sample traffic patterns for a series of cross city driving cycles in Perth, Western Australia.
Newman, P. W. G., Lyons, T. J., Kenworthy, J. R.   +2 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Enhanced socially oriented mission-based driving cycles generation and simulation framework for light electric vehicles

Humanities & Social Sciences Communications
Standard driving cycles are commonly used to assess vehicle performance and to design and optimize vehicle powertrains. However, these standard driving cycles lack some details, especially regarding slopes, curves, traffic variability, or weather ...
Petr Hajduk, Mikaela Ranta, Mehrnaz Farzam Far, Jenni Pippuri-Mäkeläinen, Joel Anttila, Mario Vukotić, Damijan Miljavec   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Interleukins drive the cell cycle

The Journal of Cell Biology, 2005
Cytokines control the number of lymphocytes in the body. Too many cytokines can lead to lymphoma; an absence to immunodeficiency. And while it is broadly known that cytokines, like IL-3 and IL-7, block apoptosis, it is less well-recognized that they promote cell proliferation. On [page 755][1],
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Construction of Battery Electric Vehicle Driving Cycles Based on Improved Grey Wolf Optimized K-Means Clustering: A Case Study for Qingdao, China

World Electric Vehicle Journal
Standardized driving cycles often inadequately represent the driving patterns specific to a particular city, and variations in vehicle types within the same city further contribute to discrepancies in driving cycles.
Rui Liang, Junnan He, Pei Lu
doaj   +1 more source