Results 91 to 100 of about 649,794 (306)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Single-phase flow and flow boiling of water in horizontal rectangular microchannels [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityThe current study is part of a long term experimental project devoted to investigating single-phase flow pressure drop and heat transfer, flow boiling ...
Mirmanto
core  

Eye Irritation Test of Soyeom Pharmacopuncture Solution for Eye Drop

Journal of Pharmacopuncture, 2008
Objectives : This study was done to investigate the safety of Soyeom pharmacopuncture solution manufactured with freezing dryness method to use eye drop.
Hyeong-sik Seo
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Scaling of fracture response in Over-height Compact Tension tests [PDF]

, 2015
An experimental investigation into in-plane scaled Over-height Compact Tension (OCT) [45/90/-45/0]4s carbon/epoxy laminates was carried out to study the scaling of fracture response.
Hallett, Stephen R., Wisnom, Michael R., Mahadik, Yusuf, Xu, Xiaodong   +3 more
core   +1 more source

Introduction of a Novel Structure for a Light Unmanned Free Balloon’s Payload: A Comprehensive Hybrid Study

Sensors
Payloads for light unmanned free balloons must meet several safety requirements such as being able to protect the inner electronics in order to extract scientific data and to reduce the chance of inflicting personal injury in case of an accidental fall ...
Norbert Hegyi, Gusztáv Fekete, János Jósvai   +2 more
doaj   +1 more source

Glass Gob Modeling and Experimental Validation Using a Drop Test

MATEC Web of Conferences, 2018
Glass blowing to create bottles with specific thickness distribution profiles requires several experimental iterations. Such iterations are expensive and increase the time to market.
Biosca Adrià, Borrós Salvador, Clemente Vicenç Pedret, Granada Andrés-Amador García   +3 more
doaj   +1 more source

Drug Drop Test: How to Quickly Identify Potential Therapeutic Compounds for Mitochondrial Diseases Using Yeast Saccharomyces cerevisiae. [PDF]

Int J Mol Sci, 2023
Magistrati M, Gilea AI, Gerra MC, Baruffini E, Dallabona C.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Improved Multi-Body Dynamic Simulation of Landing Gear Drop Test Incorporating Structural Flexibility and Bearing Contact

Aerospace
The investigation of multi-body dynamics (MBD) modeling for landing gear drop tests is a hot topic in the realm of landing gear design. The current results were primarily focused on the multi-rigid body simulation or a simple multi-flexible body ...
Wenbin Liu, Youshan Wang
doaj   +1 more source