Results 71 to 80 of about 649,794 (306)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Drop tower impact rig to assess the effectiveness of suspension seat for small high-speed passenger craft

Brodogradnja
This work aims to design a drop tower impact rig to examine the effectiveness of suspension seats for small high-speed passenger crafts and to evaluate whether the designed suspension seat can effectively mitigate the slamming impact on passengers and ...
Faisal Ikram Bin Abd Samad, Mohd Yuzri Bin Mohd Yusop, Nik Mohd Ridzuan Bin Shaharuddin, Omar Bin Yaakob   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

University Drop-out in Italy [PDF]

This paper investigates the determinants of Italian university drop-out which is one of the main issues of the tertiary education system. We provide evidence at national level as we use longitudinal data drawn from the European Community Household Panel (
Carmen Aina
core  

B-52B/DTV (Drop Test Vehicle) flight test results: Drop test missions [PDF]

, 1985
The NASA test airplane, B-52B-008, was a carrier for drop tests of the shuttle booster recovery parachute system. The purpose of the test support by Boeing was to monitor the vertical loads on the pylon hooks.
Doty, L. J.
core   +1 more source

Mechanical Characterization and Dual-Layer Discrete Element Modeling of Mactra veneriformis

Fishes
The discrete element model of Mactra veneriformis currently employs an oversimplified multi-sphere approach using EDEM’s Hertz–Mindlin model, assuming uniform shell–flesh mechanical properties. This study developed an advanced dual-layer flexible bonding
Bin Xu, Yazhou Yang, Hangqi Li, Guangcong Chen, Yizhi Chang, Feihong Guo, Hao Wu, Jixuan Zhao, Zijing Liu, Guochen Zhang, Xiuchen Li, Hanbing Zhang, Qian Zhang, Gang Mu   +13 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A fast and accurate per-cell dynamic IR-drop estimation method for at-speed scan test pattern validation [PDF]

, 2012
In return for increased operating frequency and reduced supply voltage in nano-scale designs, their vulnerability to IR-drop-induced yield loss grew increasingly apparent. Therefore, it is necessary to consider delay increase effect due to IR-drop during
13208, 13209, Hatayama, Kazumi, Inoue, Michiko, Yoneda, Tomokazu, 109, 292, 30273840, 20707244, Yamato, Yuta   +9 more
core   +1 more source

Preliminary Development and Experimental Validation of a Clustering Hybrid Rocket Module for Soft-Landing Application

Aerospace
This study presents the preliminary development of a clustered hybrid propulsion module, and its experimental validation from static motor characterization to dynamic 1-D vertical drop tests to assess the feasibility of a hybrid propulsion system for ...
Donghee Lee, Donggeun Lee, Sungwoo Park, Jungpyo Lee, Heejang Moon   +4 more
doaj   +1 more source