Results 61 to 70 of about 638,146 (260)

ANALISIS KOMPONEN WAKTU REAKSI ATLET BULUTANGKIS (STUDI PADA ATLET BULUTANGKIS DI SEMARANG)

Jurnal Kedokteran Diponegoro, 2017
Latar Belakang: Latihan rutin yang dilakukan oleh para atlet bulutangkis akan meningkatkan komponen fisik yaitu kecepatan yang ditunjukkan melalui waktu reaksi.
Amitya Ekacitta Anindita, Tanjung Ayu Sumekar, Yuswo Supatmo   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Introduction of a Novel Structure for a Light Unmanned Free Balloon’s Payload: A Comprehensive Hybrid Study

Sensors
Payloads for light unmanned free balloons must meet several safety requirements such as being able to protect the inner electronics in order to extract scientific data and to reduce the chance of inflicting personal injury in case of an accidental fall ...
Norbert Hegyi, Gusztáv Fekete, János Jósvai   +2 more
doaj   +1 more source

Drug Drop Test: How to Quickly Identify Potential Therapeutic Compounds for Mitochondrial Diseases Using Yeast Saccharomyces cerevisiae. [PDF]

Int J Mol Sci, 2023
Magistrati M, Gilea AI, Gerra MC, Baruffini E, Dallabona C.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Improved Multi-Body Dynamic Simulation of Landing Gear Drop Test Incorporating Structural Flexibility and Bearing Contact

Aerospace
The investigation of multi-body dynamics (MBD) modeling for landing gear drop tests is a hot topic in the realm of landing gear design. The current results were primarily focused on the multi-rigid body simulation or a simple multi-flexible body ...
Wenbin Liu, Youshan Wang
doaj   +1 more source

Eye Irritation Test of Soyeom Pharmacopuncture Solution for Eye Drop

Journal of Pharmacopuncture, 2008
Objectives : This study was done to investigate the safety of Soyeom pharmacopuncture solution manufactured with freezing dryness method to use eye drop.
Hyeong-sik Seo
doaj   +1 more source

Drop Test Kinematics Using Varied Impact Surfaces and Head/Neck Configurations for Rugby Headgear Testing. [PDF]

Ann Biomed Eng, 2022
Stitt D, Kabaliuk N, Alexander K, Draper N.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source