Results 71 to 80 of about 582,274 (300)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Applied Sciences, 2022 Current technology has produced a wide range of advanced micro-structured surfaces, designed for achieving the best wettability and adhesion performances for each specific application.
Giulio Croce +3 more
doaj +1 more source
Relativistic Expansion of Electron-Positron-Photon Plasma Droplets and Photon Emission
, 2010 The expansion dynamics of hot electron-positron-photon plasma droplets is dealt with within relativistic hydrodynamics. Such droplets, envisaged to be created in future experiments by irradiating thin foils with counter-propagating ultra-intense laser ...
B. Kämpfer +4 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
eLife, 2020 Within deep tissue sites, extracellular bacterial pathogens often replicate in clusters that are surrounded by immune cells. Disease is modulated by interbacterial interactions as well as bacterial-host cell interactions resulting in microbial growth ...
Stacie A Clark +6 more
doaj +1 more source
Pharmaceutics, 2022 The management of brain diseases remains a challenge, particularly because of the difficulty for drugs to cross the blood–brain barrier. Among strategies developed to improve drug delivery, nano-sized emulsions (i.e., nanoemulsions), employed as ...
Charlotte Bérard +9 more
doaj +1 more source
Water Droplets in a Spherically Confined Nematic Solvent: A Numerical Investigation
, 1998 Recently, it was observed that water droplets suspended in a nematic liquid crystal form linear chains (Poulin et al., Science 275, 1770 (1997)). The chaining occurs, e.g., in a large nematic drop with homeotropic boundary conditions at all the surfaces.
Bernhard, Ralf +2 more
core +1 more source
The dynamics of milk droplet–droplet collisions [PDF]
Experiments in Fluids, 2017 Spray drying is an important industrial process to produce powdered milk, in which concentrated milk is atomized into small droplets and dried with hot gas. The characteristics of the produced milk powder are largely affected by agglomeration, combination of dry and partially dry particles, which in turn depends on the outcome of a collision between ...
Finotello, Giulia (author) +6 more
openaire +4 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source