Results 91 to 100 of about 525,943 (299)
ComputersMiniaturization promotes the efficiency and exploration domain in scientific fields such as computer science, engineering, medicine, and biotechnology.
Bastian Oldach +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Pressure Drop in Capsule Transporting Pipeline Carrying Spherical Capsules [PDF]
, 2011 Design parameters of hydraulic pipelines in which capsules flow can be developed if pressure drops ( P/L)m are known. Designers are in need of a general correlation to calculate pressure drop.
Ubbi, Kuldip +3 more
core +3 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Frontiers in Aging Neuroscience, 2015 This study focused on the assessment of a program recently developed for helping patients with moderate Alzheimer’s disease engage in computer-mediated verbal reminiscence (Lancioni et al., 2014a). Sixteen participants were involved in the study. Six of
Giulio E. Lancioni +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Flow measurement using micro-PIV and related temperature distributions within evaporating sessile drops of self-rewetting mixtures of 1-pentanol and water [PDF]
, 2014 Recently interest has arisen in the use of so-called self-rewetting mixtures for micro-scale heattransfer systems. Such fluids, in which the surface tension can increase with increasing temperature, areexpected to offer superior evaporative cooling ...
Harmand, Souad +4 more
core
Experimental Investigation of Pendant and Sessile Drops in Microgravity
, 2010 The experiments regarding the contact angle behavior of pendant and sessile evaporating drops were carried out in microgravity environment. All the experiments were performed in the Drop Tower of Beijing, which could supply about 3.6 s of microgravity ...
Tadrist L +7 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source