Results 191 to 200 of about 428,367 (405)

Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs. [PDF]

open access: yes, 2019
One output arm of the sleep homeostat in Drosophila appears to be a group of neurons with projections to the dorsal fan-shaped body (dFB neurons) of the central complex in the brain.
Elsheikh, Ahmed   +7 more
core   +1 more source

Neurodegenerative and Neurodevelopmental Roles for Bulk Lipid Transporters VPS13A and BLTP2

open access: yesMovement Disorders, EarlyView.
Abstract Background Bridge‐like lipid transfer proteins (BLTPs) mediate bulk lipid transport at membrane contact sites. Mutations in BLTPs are linked to both early‐onset neurodevelopmental and later‐onset neurodegenerative diseases, including movement disorders.
Sarah D. Neuman   +4 more
wiley   +1 more source

Time-Varying Networks: Recovering Temporally Rewiring Genetic Networks During the Life Cycle of Drosophila melanogaster [PDF]

open access: yesarXiv, 2008
Due to the dynamic nature of biological systems, biological networks underlying temporal process such as the development of {\it Drosophila melanogaster} can exhibit significant topological changes to facilitate dynamic regulatory functions. Thus it is essential to develop methodologies that capture the temporal evolution of networks, which make it ...
arxiv  

G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis   +10 more
wiley   +1 more source

Recent selective sweeps in North American Drosophila melanogaster show signatures of soft sweeps [PDF]

open access: yesarXiv, 2013
Rapid adaptation has been observed in numerous organisms in response to selective pressures, such as the application of pesticides and the presence of pathogens. When rapid adaptation is driven by rare alleles from the standing genetic variation or by a high population rate of de novo adaptive mutation, positive selection should commonly generate soft ...
arxiv  

Polytene chromosomes as indicators of phylogeny in several species groups of Drosophila. [PDF]

open access: yes, 2001
BackgroundPolytene chromosome banding patterns have long been used by Drosophila evolutionists to infer degree of relatedness among taxa. Recently, nucleotide sequences have preempted this traditional method.
Baker, RH   +4 more
core  

Discovery and biological characterization of a novel mesoionic insecticide fenmezoditiaz

open access: yesPest Management Science, EarlyView.
Acetylcholine binding protein (AChBP) from the sea slug Aplysia californica was modified using site‐directed mutagenesis to create an insect‐like binding site enabling structure‐based compound design. Fenmezoditiaz is a systemic insecticide with a broad spectrum, lack of cross‐resistance and an additional tool for integrated pest management and ...
Huazhang Huang   +8 more
wiley   +1 more source

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