Results 11 to 20 of about 2,208,548 (262)

Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity

open access: yesPharmaceutics, 2021
We evaluated the bioavailability, liver distribution, and efficacy of silymarin-D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) solid dispersion (silymarin-SD) in rats with acetaminophen-induced hepatotoxicity (APAP) compared with silymarin ...
Im-Sook Song   +4 more
doaj   +1 more source

Fabrication of Gastro-Floating Famotidine Tablets: Hydroxypropyl Methylcellulose-Based Semisolid Extrusion 3D Printing

open access: yesPharmaceutics, 2023
Semisolid extrusion (SSE) three-dimensional (3D) printing uses drug-loaded paste for the printing process, which is capable of constructing intricate 3D structures.
Hyun Seok Yang, Dong Wuk Kim
doaj   +1 more source

Variability in In Vitro OATP1B1/1B3 Inhibition Data: Impact of Incubation Conditions on Variability and Subsequent Drug Interaction Predictions

open access: yesClinical and Translational Science, 2020
As the research into the organic anion transporting polypeptides (OATPs) continues to grow, it is important to ensure that the data generated are accurate and reproducible.
Savannah J. McFeely   +2 more
doaj   +1 more source

Assessment of potential drug interactions among psychiatric inpatients receiving antipsychotic therapy of a secondary care hospital, United Arab Emirates

open access: yesJournal of Advanced Pharmaceutical Technology & Research, 2021
The majority of the antipsychotic drugs are also known to interact with other co-administered drugs. Drug–drug interaction (DDI) reports among patients receiving antipsychotic medications are common.
Haneen A. R. Aburamadan   +2 more
doaj   +1 more source

Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability, Photostability, and Permeability

open access: yesPharmaceutics, 2022
The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX).
Bhupendra Raj Giri   +5 more
doaj   +1 more source

Current Concepts on Drug Abuse and Dependence [PDF]

open access: yes, 2015
Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza   +5 more
core   +3 more sources

A network inference method for large-scale unsupervised identification of novel drug-drug interactions [PDF]

open access: yes, 2013
Characterizing interactions between drugs is important to avoid potentially harmful combinations, to reduce off-target effects of treatments and to fight antibiotic resistant pathogens, among others.
Guimera, Roger, Sales-Pardo, Marta
core   +4 more sources

Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

open access: yesPharmaceutics, 2022
Ursodeoxycholate (UDCA) has low oral bioavailability and pH-dependent solubility and permeability. Thus, we developed a pH-modified extended-release formulation of UDCA using Na2CO3 as the alkalizing agent and hydroxypropyl methylcellulose (HPMC) as the ...
Jaehyeok Lee   +5 more
doaj   +1 more source

Role of Computerized Physician Order Entry Usability in the Reduction of Prescribing Errors [PDF]

open access: yes, 2013
Some hospitals have implemented computerized physician order entry (CPOE) systems to reduce the medical error rates. However, research in this area has been very limited, especially regarding the impact of CPOE use on the reduction of prescribing errors.
Elhissi, Abdelbary   +4 more
core   +2 more sources

The impact of worker values on client outcomes within a drug treatment service [PDF]

open access: yes, 2008
Background: Little attention has been paid to understanding the impact of values, attributes and characteristics of drugs workers on therapeutic relationships and treatment outcomes.
Bourne, RHL, Phillips, R
core   +2 more sources

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