Results 21 to 30 of about 1,104,169 (198)

Chorismate synthase mediates cerebral malaria pathogenesis by eliciting salicylic acid-dependent autophagy response in parasite

Biology Open, 2020
Cerebral malaria caused by Plasmodium falciparum is the severest form of the disease resulting in the morbidity of a huge number of people worldwide. Development of effective curatives is essential in order to overcome the fatality of cerebral malaria ...
Malabika Chakrabarti, Deepika Kannan, Akshay Munjal, Hadi Hasan Choudhary, Satish Mishra, Shailja Singh   +5 more
doaj   +1 more source

Drug-drug interaction-related uncontrolled glycemia

Journal of Pharmacy and Bioallied Sciences, 2017
Context: The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited. Aims: The aim of this
Mohamed Anwar Hammad, Balamurugan Tangiisuran, Abeer Mohamed Kharshid, Noorizan Abdul-Aziz, Yahaya Hassan, Nor Azizah Aziz, Tarek Mohamed Elsayed   +6 more
doaj   +1 more source

MOESM2 of Potential drugâ drug interactions among elderly patients admitted to medical ward of Ayder Referral Hospital, Northern Ethiopia: a cross sectional study

, 2016
Additional file 2. STROBE Statementâ checklist of items that should be included in reports of observational studies.
Fantaye Teka, Gebrehiwot Teklay, Eskindeir Ayalew, Terefe Teshome   +3 more
openaire   +1 more source

Understanding Pharmacokinetic-Drug Interactions With Drugs Approved by the US Food and Drug Administration in 2024 to Better Manage the Risk of Drug Interactions With Concomitant Medications: A Review of Clinical Data From New Drug Applications

Current Therapeutic Research
Objective: This analysis aimed to provide a mechanistic understanding and an evaluation of the clinical relevance of pharmacokinetic drug-drug interactions (DDIs) associated with drugs approved by the Food and Drug Administration in 2024.
Jingjing Yu, MD, PhD, Sophie Argon, PharmD, Katie Owens, BPharm, PhD, Yan Wang, MS, Isabelle Ragueneau-Majlessi, MD, MS   +4 more
doaj   +1 more source

Additional file 1: of Research on the mechanism of drugâ drug interaction between salvianolate injection and aspirin based on the metabolic enzyme and PK-PD model: study protocol for a PK-PD trial

, 2018
SPIRIT 2013 checklist. (DOC 108 kb)
Zhang, Wantong, Zhu, Baochen, Cao, Weiyi, Li, Rui, Wang, Shuge, Gao, Rui   +5 more
openaire   +1 more source

Metabolite Measurement in Index Substrate Drug Interaction Studies: A Review of the Literature and Recent New Drug Application Reviews

Metabolites
Background/Objectives: Index substrates are used to understand the processes involved in pharmacokinetic (PK) drug–drug interactions (DDIs). The aim of this analysis is to review metabolite measurement in clinical DDI studies, focusing on index ...
Jingjing Yu, Nathalie Rioux, Iain Gardner, Katie Owens, Isabelle Ragueneau-Majlessi   +4 more
doaj   +1 more source

IMSE: interaction information attention and molecular structure based drug drug interaction extraction

BMC Bioinformatics, 2022
Background Extraction of drug drug interactions from biomedical literature and other textual data is an important component to monitor drug-safety and this has attracted attention of many researchers in healthcare.
Biao Duan, Jing Peng, Yi Zhang
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source