Results 11 to 20 of about 1,977,916 (307)

Neuronal stem cell-drug interactions : a systematic review and meta-analysis [PDF]

, 2019
Stem cell therapy is a promising treatment option for neurodegenerative diseases that mostly affect geriatric patients who often suffer from comorbidities requiring multiple medications.
Boltze, Johannes, Ikhsan, Maulana, Palumbo, Alex, Rose, Dorothee, Zille, Marietta   +4 more
core   +1 more source

Natural products in drug discovery: meeting the urgency for new antimicrobials for human and veterinary use

AIMS Molecular Science, 2023
The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases.
Marcus Vinícius Dias-Souza, Arthur Azevedo Perpétuo, Gabriel Souza dos Santos, Luiz Felipe Carreiro Machado , Renan Martins dos Santos   +4 more
doaj   +1 more source

Provenance-Centered Dataset of Drug-Drug Interactions [PDF]

, 2015
Over the years several studies have demonstrated the ability to identify potential drug-drug interactions via data mining from the literature (MEDLINE), electronic health records, public databases (Drugbank), etc.
A Callahan, A Gottlieb, B Mons, DS Wishart, J Lazarou, K Haerian, L Zhang, M Dumontier, NP Tatonetti, P Avillach, P Groth, RL Bushardt, S Vilar, SV Iyer, T Kuhn   +14 more
core   +3 more sources

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
core   +1 more source

A network inference method for large-scale unsupervised identification of novel drug-drug interactions [PDF]

, 2013
Characterizing interactions between drugs is important to avoid potentially harmful combinations, to reduce off-target effects of treatments and to fight antibiotic resistant pathogens, among others.
Guimera, Roger, Sales-Pardo, Marta
core   +4 more sources

Choosing the safest acute combination therapy during prophylactic treatment. pharmacokinetic and pharmacodynamic considerations [PDF]

, 2015
Drugs used in the treatment of migraine have been recently reported to be highly associated with the occurrence of clinically significant drug-drug interactions (DDIs)
Lionetto, Luana, MARTELLETTI, Paolo
core   +1 more source

Potential drug-drug interactions and prescription errors in COVID-19 infected patients

Public Health and Toxicology, 2023
Introduction Prescription errors can cause havoc during the pandemic, especially for comorbid patients with diabetes and hypertension identified as a risky population group for COVID-19.
Syeda R. Tasfia, Hujaifa A. Sakib, Tasmiah Khanam, Nazia Hoque, Mamunur Rahman, Arif Khan, Sufia Islam   +6 more
doaj   +1 more source

Adverse reactions of amiodarone [PDF]

, 2019
Adverse drug reaction is defined by the World Health Organization as any response to a drug that is noxious and unintended and occurs at a dose normally used in man.
Calvosa, Leonardo, Ciacciarelli, Marco, Colunga Biancatelli, Ruben Ml, Congedo, Viviana, Iuliano, Luigi, Polidoro, Alessandro   +5 more
core   +1 more source

Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions: Risk factors and impact on indicators of health-related quality of life

Population Medicine, 2022
Introduction While studies have extensively examined the clinical and pharmacokinetic correlates of drug-drug interactions (DDIs) with antiretroviral therapy (ART), less is known about DDIs from the perspective of people living with HIV (PLHIV). Among an
Sejun Park, Yu-Hsiang Hsiao, Fei Yu, Keita Kambara, Brent Allan, Garry Brough, Ta-Fen Hwang, Nathalie Dang, Benjamin Young, Rickesh Patel, Andres Maldonado, Chinyere Okoli   +11 more
doaj   +1 more source