Results 241 to 250 of about 2,006,164 (309)

2D interaction of compound 6e (left) and indomethacin drug (right) within the active site of cyclooxygenase-1 (COX-1) (PDB ID: 1EQG).

Yasser Hussein Issa Mohammed (17140711), Ahmed Hassen Shntaif (22320292), Saad Alghamdi (362506), Ahd A. Mansour (21660692), Naeem F. Qusty (15416890), Azhar S. Sindi (13259916), Ahmad O. Babalghith (15279713), Ghazi A. Bamagous (22320295), Eman Adnan Abu-Seer (22320298)   +8 more
openalex   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Point-Prevalence of Antimicrobial-Related Potential Drug-Drug Interactions in Hospitalized Older Adults: A Multicenter Study Using Lexicomp. [PDF]

J Clin Med
Arslan Y, Gürbüz E, Alkan S, Vurucu S, Çiçek Y, Özkaraman Y, Deniz M, Hakseven-Karaduman Z, Baran Aİ, Çelik M, Ceylan MR, İrdem T, Akgül F, Altındağ D, Sevim-Akıl Ş, Agüloğlu-Bali E, Çelen MK.   +16 more
europepmc   +1 more source

Behavioural and Pharmacological Interactions between Drug and Nutritional Reinforcers

, 2018
Meenu Minhas
openalex   +1 more source

Docking aggregates and elaborate interaction of Afimetoran drug with wild and nsSNPs (R28Q, T40M, P59L, R200C), containing key residues, distances, angles and binding energies.

Obaid Habib (22615046), Saqib Ishaq (22615049), Kamran Habib (22615052), Aishma Khattak (11261634), Wei Yang (109917), Zesong Li (151039), Kainat Bukhari (22615055), Amin Ullah (12015113), Ajaz Ahmad (1408756), Qurban Ali (3700123)   +9 more
openalex   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Clinical assessment of mocravimod as a victim of drug-drug interactions via CYP3A4 metabolism and transporters. [PDF]

Clin Pharmacol Drug Dev
Huntjens DR, Oehen S, Kueenburg E.
europepmc   +1 more source

Supplementary file 1_Polypharmacy, drug–drug interactions and adverse drug reactions in older Chinese cancer patients: evidence from CHARLS.docx

Zijun Yan (8603262), Ke-qin Fan (21442289), Ting Yu (156230), Ning Su (635681), Yan Zou (309215), Liangjing Xia (21442292)   +5 more
openalex   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source