Results 21 to 30 of about 6,612,897 (317)

Prevalence and Clinical Significance of Drug–Drug and Drug–Dietary Supplement Interactions among Patients Admitted for Cardiothoracic Surgery in Greece

Pharmaceutics, 2021
Background: Drug interactions represent a major issue in clinical settings, especially for critically ill patients such as those with cardiovascular disease (CVD) who require cardiothoracic surgery (CTS) and receive a high number of different medications.
Marios Spanakis, Maria Melissourgaki, George Lazopoulos, Athina E. Patelarou, Evridiki Patelarou   +4 more
doaj   +1 more source

Natural products in drug discovery: meeting the urgency for new antimicrobials for human and veterinary use

AIMS Molecular Science, 2023
The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases.
Marcus Vinícius Dias-Souza, Arthur Azevedo Perpétuo, Gabriel Souza dos Santos, Luiz Felipe Carreiro Machado , Renan Martins dos Santos   +4 more
doaj   +1 more source

Evaluation of Pharmacokinetic Drug–Drug Interactions: A Review of the Mechanisms, In Vitro and In Silico Approaches

Metabolites, 2021
Pharmacokinetic drug–drug interactions (DDIs) occur when a drug alters the absorption, transport, distribution, metabolism or excretion of a co-administered agent.
Yaru Peng, Zeneng Cheng, Feifan Xie
semanticscholar   +1 more source

Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice

Pharmaceutics, 2020
In an ageing society, polypharmacy has become a major public health and economic issue. Overuse of medications, especially in patients with chronic diseases, carries major health risks. One common consequence of polypharmacy is the increased emergence of
M. Deodhar, Sweilem B Al Rihani, Meghan J. Arwood, Lucy I. Darakjian, Pamela Dow, J. Turgeon, V. Michaud   +6 more
semanticscholar   +1 more source

A machine learning framework for predicting drug–drug interactions

Scientific Reports, 2021
Understanding drug–drug interactions is an essential step to reduce the risk of adverse drug events before clinical drug co-prescription. Existing methods, commonly integrating heterogeneous data to increase model performance, often suffer from a high ...
Suyu Mei, Kun Zhang
semanticscholar   +1 more source

Potential drug-drug interactions and prescription errors in COVID-19 infected patients

Public Health and Toxicology, 2023
Introduction Prescription errors can cause havoc during the pandemic, especially for comorbid patients with diabetes and hypertension identified as a risky population group for COVID-19.
Syeda R. Tasfia, Hujaifa A. Sakib, Tasmiah Khanam, Nazia Hoque, Mamunur Rahman, Arif Khan, Sufia Islam   +6 more
doaj   +1 more source

Polypharmacy and the risk of drug–drug interactions and potentially inappropriate medications in hospital psychiatry

Pharmacoepidemiology and Drug Safety, 2021
The aim of this study was to analyze the epidemiology of polypharmacy in hospital psychiatry. Another aim was to investigate predictors of the number of drugs taken and the associated risks of drug–drug interactions and potentially inappropriate ...
J. Wolff, G. Hefner, C. Normann, K. Kaier, H. Binder, C. Hiemke, S. Toto, K. Domschke, M. Marschollek, A. Klimke   +9 more
semanticscholar   +1 more source

Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions: Risk factors and impact on indicators of health-related quality of life

Population Medicine, 2022
Introduction While studies have extensively examined the clinical and pharmacokinetic correlates of drug-drug interactions (DDIs) with antiretroviral therapy (ART), less is known about DDIs from the perspective of people living with HIV (PLHIV). Among an
Sejun Park, Yu-Hsiang Hsiao, Fei Yu, Keita Kambara, Brent Allan, Garry Brough, Ta-Fen Hwang, Nathalie Dang, Benjamin Young, Rickesh Patel, Andres Maldonado, Chinyere Okoli   +11 more
doaj   +1 more source

Polypharmacy and Potential Drug–Drug Interactions in Home-Dwelling Older People – A Cross-Sectional Study

Journal of Multidisciplinary Healthcare, 2021
Background Risks associated with polypharmacy and drug–drug interactions represent a challenge in drug treatment, especially in older adults. The aim of the present study was to assess the use of prescription and non-prescription drugs and the frequency ...
Monica Hermann, Nina Carstens, Lars Kvinge, Astrid Fjell, M. Wennersberg, Kjersti Folleso, K. Skaug, Å. Seiger, B. Cronfalk, Anne-Marie Bostrom   +9 more
semanticscholar   +1 more source

Drug-drug interactions with raltegravir

European Journal of Medical Research, 2009
Objective To review all currently published drug-drug interaction studies with the HIV-integrase inhibitor raltegravir. Methods A PubMed search was conducted for all published reports up to August 1, 2009 as well as a review of updated European and US ...
Burger David M
doaj   +1 more source