Clinical Evaluation of Drug–Drug Interactions With Aficamten [PDF]
Clinical and Translational ScienceAficamten is a next‐in‐class small molecule cardiac myosin inhibitor that was recently approved by the United States Food and Drug Administration (FDA) for the treatment of symptomatic obstructive hypertrophic cardiomyopathy (oHCM).
Neha Maharao +11 more
doaj +2 more sources
Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial [PDF]
Clinical and Translational ScienceThis tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das +2 more
doaj +2 more sources
Tutorial Drug–Drug Interactions [PDF]
Clinical and Translational ScienceEdward M. Sellers
doaj +2 more sources
PRELIMINARY INVESTIGATION ON THE PRODUCTION OF SURFACE ACTIVE COMPOUNDS WITH ANTIMICROBIAL AND EMULSIFYING PROPERTIES BY BACILLUS CLAUSII AND LACTOBACILLUS RHAMNOSUS PROBIOTIC STRAINS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2021 Surface active compounds (SACs) of bacterial origin are amphiphilic heteropolymers that may alter the interaction of gas-liquid, solid-liquid, and immiscible liquids surfaces, decrease the surface and interfacial tensions of liquids, and form stable ...
Marcus Dias-Souza +2 more
doaj +1 more source
Drug-drug interactions in the hospital [PDF]
, 2007 Introduction Drug interaction screening programs are an important tool to check prescriptions of multiple drugs for potential drug-drug interactions (pDDIs). Several programs are available on the market.
Priska Vonbach
openalex +3 more sources
Pharmacokinetic Drug–Drug Interactions and Herb–Drug Interactions
Pharmaceutics, 2021 Due to the growing use of herbal supplementation—ease of taking herbal supplements with therapeutics drugs (i [...]
Min-Koo Choi, Im-Sook Song
doaj +1 more source
Discovering Drug-Drug Interactions Using Association Rule Mining from Electronic Health Records [PDF]
, 2023 In this paper, we propose utilising Electronic Health Records (EHR) to discover previously unknown drug-drug interactions (DDI) that may result in high rates of hospital readmissions.
Chahed, S. +4 more
core +1 more source
Predicting drug-target interactions using drug-drug interactions. [PDF]
PLoS ONE, 2013 Computational methods for predicting drug-target interactions have become important in drug research because they can help to reduce the time, cost, and failure rates for developing new drugs.
Shinhyuk Kim, Daeyong Jin, Hyunju Lee
doaj +1 more source
Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding [PDF]
PeerJ, 2018 The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms.
Alexey Smirnov +4 more
doaj +2 more sources
Drug-drug interactions of tacrolimus [PDF]
Hospital Pharmacology, 2015 Introduction: Tacrolimus, potent immunosupressive drug, has large inter- and intraindividual pharmacokinetic variability. The aim: The aim of this current topic is to describe the importance of tacrolimus drug-drug interactions.
Rančić Nemanja K. +4 more
doaj +1 more source