A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors [PDF]
, 2013 Scott J. Brantley +3 more
openalex +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Evaluation of Drug–Polymer and Drug–Drug Interaction in Cellulosic Multi-Drug Delivery Matrices
Methods and ProtocolsMulti-drug delivery systems have gained increasing interest from the pharmaceutical industry. Alongside this is the interest in amorphous solid dispersions as an approach to achieve effective oral delivery of compounds with solubility-limited ...
Abdullah Isreb +8 more
doaj +1 more source
Interaction of innovative small molecule drugs used for cancer therapy with drug transporters [PDF]
, 2011 Kathrin Mandery +2 more
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Elucidating Signal Transduction Modulatory Drug Target Network of Colon Cancer: A Network Biology Approach [PDF]
, 2010 Latest evaluation and validation of cancer drugs and their targets has demonstrated the lack and inadequate development of new and better drugs, based on available protocols.
Biplab Bhattacharjee +5 more
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Physicians’ awareness and use of drug-drug interactions software: A preliminary study
Ibom Medical JournalBackground: Drug-drug interactions software is used as a tool to investigate clinically harmful interactions. Prescribers need to be aware of these tools to improve the quality of drug prescriptions, thus ensuring better patient care.
Oriaifo OG, Opadeyi AO, Isah AO
doaj +1 more source
Leveraging genetic interactions for adverse drug-drug interaction prediction.
PLoS Computational Biology, 2019 In light of increased co-prescription of multiple drugs, the ability to discern and predict drug-drug interactions (DDI) has become crucial to guarantee the safety of patients undergoing treatment with multiple drugs. However, information on DDI profiles
Sheng Qian, Siqi Liang, Haiyuan Yu
doaj +1 more source
The Effect of Configuration to Interaction Energy Between The Segments of Chitosan and Ascorbic Acid Molecule: Theoretical Study of Drug Release Control [PDF]
, 2015 Polymer systems plays an important role in drug delivery, which can control the time release of the drug, reduce the rate of degradation of the drug, and can reduce the toxic properties of the drug.
Hildayani, Suci Zulaikha +1 more
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