Results 201 to 210 of about 2,202,582 (329)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Drug-Drug Interaction Management Among Pharmacists in Jordan: A National Comparative Survey. [PDF]

Pharmacy (Basel)
Abdel-Qader DH, Al-Kubaisi KA, Taybeh E, Al Mazrouei N, Ibrahim R, Albassam A.   +5 more
europepmc   +1 more source

Antiparkinsonian drugs, mental disorders in patients with Parkinson's disease and drug‑drug interactions [PDF]

, 2018
Michal Prokeš, Josef Suchopár
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Assessment of Potential Drug–Drug Interactions and Their Predictors in Chronic Outpatient Department of Dessie Referral Hospital, Dessie, Northeast Ethiopia

, 2021
Mengistie Yirsaw Gobezie, Hailu Birhanu Bitew, Abdu Tuha, Haftom Gebregergs Hailu   +3 more
openalex   +2 more sources

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

DDI-CYP: Metabolism ensemble models for drug-drug interaction predictions. [PDF]

Drug Metab Dispos
Wong JT, Harris JS, Lane TR, Urbina F, Ekins S.   +4 more
europepmc   +1 more source

Host–Pathogen Interaction Mapping in Drug-Resistant Tuberculosis: A Systems Biology Framework for Dual Therapeutic Targeting [PDF]

Onwu Daniel Ocha, Anmol Singh, Yashi Bajpai, Akinlamilo Adeyemi Sunday, Adele Habiganuchi, Felix Oladunjoye Ibikunle   +5 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

A meta-contrastive learning approach for clinical drug-drug interaction extraction from biomedical literature. [PDF]

PLoS Comput Biol
Jia Y, Yuan Z, Zhu L, Xiang ZL.
europepmc   +1 more source