Results 221 to 230 of about 2,242,237 (349)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Contrastive learning-based multi-mechanism disentangled assessment for drug-drug interaction. [PDF]

BMC Bioinformatics
Zhang J, Zeng Y, Tang C, Zhong C, Wen H, Liu Y.   +5 more
europepmc   +1 more source

Baseline Assessment of Drug-Drug Interaction Knowledge Among Healthcare Providers in Kibaha, Tanzania

Ally Salim, Megan Allen, Kelvin Mariki, Thomas Pallangyo, Rose Maina, Fatma Ally, Moses Minja, Kelvin Msovela, Jafary Liana   +8 more
openalex   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

UGT2B7-mediated drug-drug interaction between cannabinoids and hydromorphone. [PDF]

Drug Metab Dispos
Coates S, Bardhi K, Zhao M, Lazarus P.
europepmc   +1 more source

Drug Interactions. II. Binding of Some Pyrazolone and Pyrazolidine Derivatives to Bovine Serum Albumin

, 1974
Shoji Ozeki, Kikuo Tejima
openalex   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

<i>In silico</i> and <i>in vitro</i> investigations of the drug-drug interaction mechanisms between fludarabine and busulfan. [PDF]

Front Pharmacol
Ben Hassine K, Robin S, Baleydier F, Mseddi M, Mlakar V, Muthukumaran J, Ansari M, Satyanarayana Uppugunduri CR.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A Dose-Aware Model for Revealing Dose-Risk Relationship of Drug-Drug Interaction. [PDF]

CPT Pharmacometrics Syst Pharmacol
Shi Y, Sun A, Yang Y, Nan H, Xu J, Shan M, Eadon MT, Su J, Zhang P.   +8 more
europepmc   +1 more source