Results 231 to 240 of about 2,242,237 (349)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Drug-Drug Interaction Management Among Pharmacists in Jordan: A National Comparative Survey. [PDF]

Pharmacy (Basel)
Abdel-Qader DH, Al-Kubaisi KA, Taybeh E, Al Mazrouei N, Ibrahim R, Albassam A.   +5 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

MHAFR-DDI: a multimodal hierarchical attention fusion and relation-aware architecture for drug-drug interaction event prediction. [PDF]

Brief Bioinform
Li M, Cao C, Zou Q, Wei L, Wang Y.
europepmc   +1 more source

Additional file 5: of Predicting drug target interactions using meta-path-based semantic network analysis

, 2016
Gang Fu, Ying Ding, Abhik Seal, Bin Chen, Yizhou Sun, Evan Bolton   +5 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Knowledge, attitudes, practices, and barriers toward drug-drug interaction management among pharmacists in Riyadh, Saudi Arabia: a cross-sectional study. [PDF]

Front Public Health
AlOmeir O, Alanazi AKR, Alnhas MA, Ajarem MA, Hafiz ZJ, AbdulMuqeet S, Alanazi SM, Alshammari MS, ALjanobi HK, Alotaibi H, Alhamad D, Aldhahri N, AlJuaie MA, Asdaq SMB.   +13 more
europepmc   +1 more source

Assessment of the Intestinal CYP3A Contribution to Drug Interactions with Extended‐Release Tacrolimus (LCPT) Using Grapefruit Juice

Adekunle Alabi, Janice Kerr, Mita M. Shah, Adnan Khan, Joseph D. Ma, Raymond T. Suhandynata, Jeremiah D. Momper, Shirley M. Tsunoda   +7 more
openalex   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

DDI-CYP: Metabolism ensemble models for drug-drug interaction predictions. [PDF]

Drug Metab Dispos
Wong JT, Harris JS, Lane TR, Urbina F, Ekins S.   +4 more
europepmc   +1 more source