Results 211 to 220 of about 2,202,582 (329)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Drug interaction (17. combination with hyperlipidemia) [PDF]

, 2010
Kawasaki, Yoichi, Matsunaga, Hisashi, Sendo, Toshiaki   +2 more
core   +2 more sources

Utility of physiologically based pharmacokinetic modeling in predicting and characterizing clinical drug interactions [PDF]

R. Foti
openalex   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Research on drug-drug interaction prediction using capsule neural network based on self-attention mechanism. [PDF]

BMC Bioinformatics
Chen X, Wang Z, Miao Z, Nie B.
europepmc   +1 more source

Amsacrine as a Topoisomerase II Poison: Importance of Drug–DNA Interactions

, 2012
Adam C. Ketron, William A. Denny, David E. Graves, Neil Osheroff   +3 more
openalex   +2 more sources

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

PS3N: leveraging protein sequence-structure similarity for novel drug-drug interaction discovery. [PDF]

Sci Rep
Islam S, Abbasi A, Agarwal N, Zheng W, Doretto G, Adjeroh DA.   +5 more
europepmc   +1 more source

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

David T. McSwiggen, Helen Liu, Ruensern Tan, Sebastia Agramunt Puig, Lakshmi B. Akella, Russell Berman, Mason Bretan, Hanzhe Chen, Xavier Darzacq, Kelsey Ford, Ruth Godbey, Eric Gonzalez, Adi Hanuka, Alec Heckert, Jaclyn J. Ho, Stephanie Johnson, Reed Kelso, Aaron Klammer, Ruchira Krishnamurthy, Jifu Li, Kevin Lin, Brian Margolin, Patrick McNamara, Laurence Meyer, Sarah E. Pierce, Akshay Sule, Connor Stashko, Yangzhong Tang, Daniel J. Anderson, Hilary P. Beck   +29 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source