Results 251 to 260 of about 2,202,582 (329)

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Drug-drug interaction analysis based on information bottleneck graph neural network: A review. [PDF]

Medicine (Baltimore)
Wang S.
europepmc   +1 more source

ANALYSIS OF DRUG INTERACTIONS IN HYPERTENSIVE PATIENTS

Nascimento, Andrey, Lima, Gabriel, Giorgi, Nicolas, Nascimento, Paulo, Neto, Walter, Del Rey, Barbara   +5 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Drug-drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450. [PDF]

Br J Clin Pharmacol
Purohit VS, Huh Y, Dowty ME, Plotka A, Lejeune A, Kalluru H, Hee B.   +6 more
europepmc   +1 more source

SGCL-DPI: structure-guided curriculum learning for drug-protein interaction prediction [PDF]

Othman Soufan
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

In Vitro Evaluation of Drug-Drug Interaction Between Gliclazide and Antacids at the Absorption Level. [PDF]

Pharmaceuticals (Basel)
Lazarević S, Kosijer S, Đanić M, Zaklan D, Stanimirov B, Mikov M, Pavlović N.   +6 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Discordance in Drug-Drug Interaction Alerts for Antidotes: Comparative Analysis of Electronic Databases and Interpretive Insights from AI Tools. [PDF]

Drug Des Devel Ther
Yaowaluk T, Tangpanithandee S, Techapichetvanich P, Khemawoot P.   +3 more
europepmc   +1 more source