Results 51 to 60 of about 5,892,906 (287)

Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug‐Drug Interaction Evaluation: Perspectives From the International Transporter Consortium

Clinical pharmacology and therapy, 2018
Drug transporters can govern the absorption, distribution, metabolism, and excretion of substrate drugs and endogenous substances. Investigations to examine their potential impact to pharmacokinetic (PK) drug‐drug interactions (DDIs) are an integral part
X. Chu, M. Liao, Hong Shen, Kenta Yoshida, A. Zur, V. Arya, A. Galetin, K. Giacomini, Imad Hanna, H. Kusuhara, Yurong Lai, D. Rodrigues, Y. Sugiyama, M. Zamek-Gliszczynski, Lei Zhang   +14 more
semanticscholar   +1 more source

Evidence of a clinically significant drug‐drug interaction between cannabidiol and tacrolimus

American Journal of Transplantation, 2019
Cannabidiol (CBD), a major purified nonpsychoactive component of cannabis with anticonvulsant properties, was approved by the U.S. Food and Drug Administration (FDA) in June 2018 as an adjuvant treatment for refractory epilepsy (Epidiolex; GW ...
A. Leino, C. Emoto, T. Fukuda, M. Privitera, A. Vinks, R. Alloway   +5 more
semanticscholar   +1 more source

Drug combinations targeting antibiotic resistance

npj Antimicrobials and Resistance
While the rise of antibiotic resistance poses a global health challenge, the development of new antibiotics has slowed down over the past decades. This turned the attention of researchers towards the rational design of drug combination therapies to ...
Bence Bognár, Réka Spohn, Viktória Lázár   +2 more
doaj   +1 more source

Evaluation of knowledge graph embedding approaches for drug-drug interaction prediction in realistic settings

BMC Bioinformatics, 2019
Current approaches to identifying drug-drug interactions (DDIs), include safety studies during drug development and post-marketing surveillance after approval, offer important opportunities to identify potential safety issues, but are unable to provide ...
R. Çelebi, Hüseyin Uyar, Erkan Yasar, Ozgur Gumus, Oguz Dikenelli, M. Dumontier   +5 more
semanticscholar   +1 more source

Interaction of an Antituberculosis Drug with a Nanoscopic Macromolecular Assembly: Temperature-Dependent Förster Resonance Energy Transfer Studies on Rifampicin in an Anionic Sodium Dodecyl Sulfate Micelle [PDF]

, 2011
In this contribution, we report studies on the nature of binding of a potent antituberculosis drug, Rifampicin (RF) with a model drug delivery system, sodium dodecyl sulfate (SDS) micelle.
Makhal, Abhinandan, Mondol, Tanumoy, Pal, Samir Kumar, Rajdev, Priya   +3 more
core  

Chemically cross-linked poly(acrylic-co-vinylsulfonic) acid hydrogel for the delivery of isosorbide mononitrate. [PDF]

, 2013
We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels.
Ansari, Mahvash, Hussain, Talib, Khan, Ikram Ullah, Ranjha, Nazar Muhammad, Shahzad, Yasser   +4 more
core   +2 more sources

Drug-Drug Interaction Pattern Recognition [PDF]

Drugs in R & D, 2010
Drug-drug interaction (DDI) is an important aspect of drug development, especially for safety. When a drug is used concomitantly with other drug(s), one of the major concerns is the change of exposures, including the rate and extent of drug absorption, distribution, metabolism and elimination.
openaire   +2 more sources

Kajian Potensi Interaksi Obat Antihipertensi Pada Pasien Hipertensi Primer Di Instalasi Rawat Jalan RSUD Luwuk Periode Januari – Maret 2016 [PDF]

, 2017
KAJIAN POTENSI INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI PRIMER DI INSTALASI RAWAT JALAN RSUD LUWUK PERIODE JANUARI – MARET 2016 Yesia Stevani Mahamudu1), Gayatri Citraningtyas1), Henki Rotinsulu1)1)Program studi farmasi FMIPA UNSRAT Manado ...
Mahamudu, Y. S. (Yesia)
core   +2 more sources

Drug drug interaction extraction from biomedical literature using syntax convolutional neural network

Bioinform., 2016
Motivation: Detecting drug-drug interaction (DDI) has become a vital part of public health safety. Therefore, using text mining techniques to extract DDIs from biomedical literature has received great attentions.
Zhehuan Zhao, Zhihao Yang, Ling Luo, Hongfei Lin, Jian Wang   +4 more
semanticscholar   +1 more source

Announcing the 2015 Viruses Young Investigator Prize and Graduate Student/Postdoctoral Fellow Travel Awards

Viruses, 2015
With the goal of recognizing outstanding contributions to the field of virology by early-career investigators, last year Viruses accepted nominations for a 2015 Young Investigator Prize in Virology. The target age was set at 40 and under.
Eric O. Freed
doaj   +1 more source