Results 71 to 80 of about 2,001,669 (363)

Drug–drug interactions in pediatric oncology patients [PDF]

, 2017
BackgroundDrug–drug interactions (DDIs) can negatively affect pharmacotherapy. However, pediatric DDI studies are scarce. We undertook an exploratory study to investigate prevalence and clinical relevance of DDIs between cytostatic and noncytostatic ...
Balk, T. E., der Sijs, I. H., der Sluis, I. M., Engels, F. K., Gelder, T., Janssen, J. J. B., Leeuwen, R. W. F.   +6 more
core   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Evaluation of resources for analyzing drug interactions

Journal of the Medical Library Association, 2017
Objective: The research sought to evaluate seven drug information resources, specifically designed for analyzing drug interactions for scope, completeness, and ease of use, and determine the consistency of content among the seven resources.
Risha I. Patel, Robert D. Beckett
doaj   +1 more source

Influence of drug–drug interactions on effectiveness and safety of direct-acting antivirals against hepatitis C virus [PDF]

, 2019
[Abstract] Objectives Direct-acting antivirals are the recommended treatment for hepatitis C-infected patients. Drug–drug interactions with concomitant treatments can cause lack of effectiveness and/or safety.
Castro-Iglesias, Ángeles, Cid-Silva, Purificación, Fernández-Oliveira, Carla, Giménez-Arufe, Víctor, Margusino-Framiñán, Luis, Martín-Herranz, Isabel, Mena, Álvaro, Mondelo-García, Cristina   +7 more
core   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

A pilot study to determine the occurrence of concomitant diseases and drug intake in patients on antituberculosis therapy

Journal of Family Medicine and Primary Care, 2018
Introduction: Altered pharmacokinetics of antituberculosis (anti-TB) drugs due to interaction with non-TB medications or concomitant diseases may lead to suboptimal plasma levels of the affected drugs and hence contribute to the emergence of drug ...
Ratinder Jhaj, Shweta Sharma, Mohammed Sabir, Arun Kokane   +3 more
doaj   +1 more source

Spatial organization and interactions of harvester ants during foraging activity [PDF]

, 2017
Local interactions, when individuals meet, can regulate collective behavior. In a system without any central control, the rate of interaction may depend simply on how the individuals move around. But interactions could in turn influence movement; individuals might seek out interactions, or their movement in response to interaction could influence ...
arxiv   +1 more source

Strongly interacting one-dimensional quantum gas mixtures with weak p-wave interactions [PDF]

Phys. Rev. A 93, 033636 (2016), 2015
We study one-dimensional strongly interacting quantum gas mixtures, including both the Bose-Fermi and spin-1/2 Fermi-Fermi mixtures, with weak p-wave interactions between intra-component fermions, and demonstrate that the weak p-wave interaction can not be omitted in the strongly interacting regime where the strength of p-wave interactions is ...
arxiv   +1 more source

TO ESTIMATE THE INCIDENCE OF POTENTIAL DRUG-DRUG INTERACTION IN STROKE PATIENTS ADMITTED IN A TERTIARY CARE HOSPITAL, TELANGANA [PDF]

, 2020
Objective: To determine the frequency and pattern of potential drug-drug interactions in hospitalized stroke patients. Methods: A retrospective study was carried out among patients treated for ischemic and haemorrhagic stroke at a tertiary care hospital,
AHMED, MOHAMMAD FARHAN, ALI, NILOUFER, ANITHA, N., AWAD, SAFA AMREEN SALIM, FATIMA, AFIFA, FIRDOUS, SIDRAH   +5 more
core   +1 more source

Local and global modes of drug action in biochemical networks [PDF]

, 2008
It becomes increasingly accepted that a shift is needed from the traditional target-based approach of drug development to an integrated perspective of drug action in biochemical systems. We here present an integrative analysis of the interactions between
A Ma'ayan, A Petrelli, C Lengauer, DB Kell, DS Lee, DS Wishart, EC Butcher, F Matthäus, F Sams-Dodd, GV Paolini, J Barthelmes, J Raymond, JA DiMasi, JC Nacher, Jean-Marc Schwartz, JH Kim, JJ Hornberg, Jose C Nacher, M Kanehisa, MA Yıldırım, MC Fishman, MI Siegel, O Ebenhöh, P Csermely, SB Seidman, T Handorf, T Handorf, T Handorf, T Handorf, V Batagelj, Z Spiro   +30 more
core   +4 more sources