Developing a molecular roadmap of drug-food interactions. [PDF]
PLoS Comput Biol, 2015 Recent research has demonstrated that consumption of food -especially fruits and vegetables- can alter the effects of drugs by interfering either with their pharmacokinetic or pharmacodynamic processes.
Jensen K +3 more
europepmc +13 more sources
ArcDFI: Attention regularization guided by CYP450 interactions for predicting drug-food interactions. [PDF]
PLoS Comput BiolCYP450 isoenzymes are known to be deeply involved in the formation of drug-food interactions (DFI). Previously introduced computational approaches for predicting DFIs do not take drug-CYP450 interactions (DCI) into account and have limited generalizability in handling compounds unseen during model training.
Gim M, Kang J, Park D, Jeon M.
europepmc +2 more sources
Deep learning improves prediction of drug-drug and drug-food interactions. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance Drug interactions, including drug–drug interactions (DDIs) and drug–food constituent interactions, can trigger unexpected pharmacological effects such as adverse drug events (ADEs). Several existing methods predict drug interactions, but require detailed, but often unavailable drug information as inputs, such as drug targets.
Ryu JY, Kim HU, Lee SY.
europepmc +5 more sources
The role of biotransformation processes in mediating interactions between psychotropic drugs and natural products [PDF]
, 2020 Many patients are not aware that natural products such as fruit juices or plant infusions can cause significant interactions with several drugs, some of which can be dangerous, especially when the medical treatment is for neurological or psychiatric ...
Bacinschi, Nicolae +6 more
core +2 more sources
In vivo selection of resistant E. coli after ingestion of milk with added drug residues. [PDF]
, 2014 Antimicrobial resistance represents a major global threat to modern medicine. In vitro studies have shown that very low concentrations of drugs, as frequently identified in the environment, and in foods and water for human and animal consumption, can ...
Bicalho, Rodrigo Carvalho +3 more
core +8 more sources
An evidence-based review of edoxaban and its role in stroke prevention in patients with nonvalvular atrial fibrillation. [PDF]
, 2015 Atrial fibrillation is the most common arrhythmia in the elderly. It is responsible for significant morbidity and mortality from cardioembolic complications like stroke.
Acharya, Tushar, Deedwania, Prakash
core +1 more source
Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]
, 2015 Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W +6 more
core +7 more sources
Whey-derived peptides interactions with ACE by molecular docking as a potential predictive tool of natural ACE inhibitors [PDF]
, 2020 Several milk/whey derived peptides possess high in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. However, in some cases, poor correlation between the in vitro ACE inhibitory activity and the in vivo antihypertensive activity has been ...
Chamata, Yara +2 more
core +1 more source
Special topic: The association between pulse ingredients and canine dilated cardiomyopathy: addressing the knowledge gaps before establishing causation. [PDF]
, 2019 In July 2018, the Food and Drug Administration warned about a possible relationship between dilated cardiomyopathy (DCM) in dogs and the consumption of dog food formulated with potatoes and pulse ingredients.
Adin +88 more
core +1 more source
Polysaccharide food matrices for controlling the release, retention and perception of flavours [PDF]
, 2018 Polysaccharides have many roles across both the food and pharmaceutics industries. They are commonly used to enhance viscosity, stabilise emulsions and to add bulk to food products.
Cook, Sarah L. +3 more
core +1 more source