Results 41 to 50 of about 735,922 (292)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Patient-centric trials for therapeutic development in precision oncology [PDF]

, 2015
An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours.
A Hollebecque, A-M Tsimberidou, AD Barker, AL Tam, Andrew V. Biankin, AT Shaw, AV Biankin, B Zhang, C Le Tourneau, C Le Tourneau, C Lin, C Printz, CK Lee, CR Lindsay, D Cook, D Slamon, D Zardavas, DD Von Hoff, DE Gerber, DJ Sargent, DT Le, EA Eisenhauer, ED Green, ES Kim, F André, GD Demetri, GM Frampton, IR Watson, J Ledermann, J Lewin, J Verweij, JA Sosman, JY Douillard, L Chin, L Chin, L Seguin, LA Chantrill, LB Alexandrov, LJ Esserman, LJ Esserman, M Hay, M Maemondo, MG Kris, MR Stratton, MR Stratton, N Roper, N Waddell, NM Hylton, PA Jänne, PN Lara Jr, R Dienstmann, R Simon, RR Kalf, S Matsumoto, S Sleijfer, Simon J. Hollingsworth, SJ Dawson, SJ Mandrekar, Steven Piantadosi, TA Yap, TJ Hudson   +60 more
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Polypharmacy in Type 2 Diabetes Mellitus: Insights from an Internal Medicine Department

Medicina, 2019
Background and Objectives: Polypharmacy heavily impacts the quality of life of patients worldwide. It is a necessary evil in many disorders, and especially in type 2 diabetes mellitus, as patients require treatment both for this condition and its related
Elena-Codruța Dobrică, Mihnea-Alexandru Găman, Matei-Alexandru Cozma, Ovidiu Gabriel Bratu, Anca Pantea Stoian, Camelia Cristina Diaconu   +5 more
doaj   +1 more source

Nutritional ergogenics aspects and drug-food interactions in mountaineering. [PDF]

, 2015
Entre los principales factores limitantes del rendimiento en el alpinismo destacan el agotamiento de los depósitos de glucógeno muscular y catabolismo proteico elevado, desequilibrio hidroelectrolítico y Mal Agudo de Montaña (MAM). Ante esta situación de
Gómez-Zorita, S., Urdampilleta, A.
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Drug-drug interactions in prescriptions of Lorestan province, Western of Iran [PDF]

, 2015
Rational prescribing means prescribing the more effective and healthiest drug for a disease according to patient’s condition, the type of effective drugs, cost and etc.
Adineh, Ahmad., Asadbeigi, Mohsen., Bahmani, Mahmoud., Bahram, Delfan., Changizian, Sehar., Rafieian-Kopaei, Mahmoud.   +5 more
core  

Is Simpler Always Better? Consumer Evaluations of Front-of-Package Nutrition Symbols [PDF]

, 2011
Consumers of packaged goods products in the United States recently have faced an onslaught of front-of-package (FOP) nutrition symbols and icons, including the controversial “Smart Choices” single summary indicator.
Andrews, J. Craig, Burton, Scot, Kees, Jeremy   +2 more
core   +3 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Copper-Induced Interactions of Caffeic Acid and Sinapic Acid to Generate New Compounds in Artificial Biological Fluid Conditions

Antioxidants, 2022
Active ingredients may be ingested through foods, and they can cause several interactions in the human body. Although drug–drug or drug–food interactions are evaluated before the approval of medicines, several functional food interactions are not well ...
Yusuke Iwasaki, Rie Manabe, Mika Kimoto, Mao Fukuda, Narumi Mase, Mako Miyazawa, Kotomi Hosokawa, Junzo Kamei   +7 more
doaj   +1 more source