Results 61 to 70 of about 640,319 (303)
The Application of Induced Pluripotent Stem Cells Against Liver Diseases: An Update and a Review
Frontiers in Medicine, 2021 Liver diseases are a major health concern globally, and are associated with poor survival and prognosis of patients. This creates the need for patients to accept the main alternative treatment of liver transplantation to prevent progression to end-stage ...
Lei Zhang +12 more
doaj +1 more source
Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. [PDF]
, 2020 Ibuprofen, an inhibitor of prostanoid biosynthesis, is a common pharmacological agent used for the management of pain, inflammation and fever. However, the chronic use of ibuprofen at high doses is associated with increased risk for cardiovascular, renal,
Gomes, Aldrin V +5 more
core
Heparanase and macrophage interplay in the onset of liver fibrosis [PDF]
, 2017 The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed at investigating the ...
Crescenzi, Marika +5 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Drug-induced liver injuries (Part 1)
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2012 The aim of review. To present modern concepts on mechanisms of drug-induced liver injury (DILI), to give their classification, to present approaches to disease diagnostics.Original positions.
S. F. Galimova
doaj
Revista Peruana de Investigación en Salud, 2021 Introduction and aim: Drug-induced liver injury (DILI) manifests as a spectrum of clinical presentations that carries morbidity and mortality. Patients with chronic liver disease (CLD), particularly hospitalized, are at high risk for developing DILI.
Rodrigo Dorelo +9 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Herbal extracts in hepatoprotection: antioxidant and immunomodulatory effects. A review [PDF]
Терапевтический архивThe global market for herbal medicines is valued at $83 billion and continues to expand rapidly. Plant extracts, widely used due to their safety and minimal side effects, play a significant role in supporting liver function.
Evgenia V. Shikh +2 more
doaj +1 more source
Journal of Evidence-Based Integrative Medicine, 2020 Liver diseases have now become a global canker due to increasing drug abuse and several viral infections. The current medicines on the market are woefully inadequate and limited in the application against these diseases.
Afua Kobi Ampem Genfi MPhil +5 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source