Results 131 to 140 of about 356,562 (324)

Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period [PDF]

, 2005
Raúl J. Andrade, M. Isabel Lucena, M. Carmen Fernández, Gloria Isabel Carvajal Peláez, Ketevan Pachkoria, Elena Garcı́a-Ruiz, B. García‐Muñoz, Rocío González‐Grande, Ángeles Pizarro, José Antonio Durán, Manuel Ramos-Jiménez, Luı́s Rodrigo, Manuel Romero–Gómez, J.M. Navarro, Ramón Planas, Joan Costa‐Font, A. A. Borras, Aina Soler, Javier Salmerón, R Martín-Vivaldi   +19 more
openalex   +1 more source

BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control.

, 2010
The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the
Cunha, Sergio S, Merle, Corinne SC, Rodrigues, Laura C   +2 more
core   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Recognizing Drug-Induced Liver Injury: Current Problems, Possible Solutions [PDF]

, 2005
William M. Lee, John Senior
openalex   +1 more source

Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model [PDF]

, 2017
There are currently no animal models of drug-induced liver injury (DILI) where the adaptive immune system has been shown to damage the liver. Thus, it is difficult to explore the mechanistic basis of the tissue injury.
Antoine, Daniel J., Faulkner, Lee, Kenna, Gerry, Kipar, Anja, Naisbitt, Dean J., Nattrass, Ryan, Nicolas, Jean-Francois, Park, B. Kevin, Vocanson, Marc   +8 more
core  

Aptamer Functionalized Hydrogel Dressings for Post‐Surgery Tumor Recurrence Inhibition and Tissue Reconstruction

Advanced Functional Materials, EarlyView.
Post‐surgical tumor therapy struggles with recurrence and inefficient healing. Anti‐tumor DNA aptamer functionalized gelatin hydrogels, Apt‐GelMA, simultaneously address both issues by suppressing tumor regrowth via targeted tumor cell inhibition and enhancing wound healing through improved cell adhesion and migration. Their biocompatibility, stability,
Tianyue Li, Xin‐Yi Qian, Zi‐Yuan Li, Hao‐Wen Li, Poh‐Ching Tan, Chenghuizi Hu, Jiajun Jin, Shuang‐Bai Zhou, Qing‐Feng Li, He Tian, Junji Zhang, Itamar Willner   +11 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Bio‐Responsive Hydrogel for Targeted on‐Demand Release of a Phage Cocktail for Treatment of Pseudomonas aeruginosa Infection

Advanced Functional Materials, EarlyView.
This study presents an injectable hydrogel that responds to Pseudomonas aeruginosa infection by releasing a dual‐phage cocktail on demand. The system degrades selectively in infected wounds, enhances phage localization and stability, and shows potent antibiofilm activity and biocompatibility in an ex vivo human skin model—offering a promising strategy ...
Siyuan Tao, Anna Hu, Elnaz Bavel, Chien‐Hsun Yu, Sixuan Zhang, Vera Maria Kissling, Zhihao Li, Thomas Fintan Moriaty, Katharina Maniura‐Weber, Qun Ren   +9 more
wiley   +1 more source

A Challenge for Diagnosing Acute Liver Injury with Concomitant/Sequential Exposure to Multiple Drugs: Can Causality Assessment Scales Be Utilized to Identify the Offending Drug?

Case Reports in Pediatrics, 2014
Drug-induced hepatotoxicity most commonly manifests as an acute hepatitis syndrome and remains the leading cause of drug-induced death/mortality and the primary reason for withdrawal of drugs from the pharmaceutical market.
Roxanne Lim, Hassan Choudry, Kim Conner, Wikrom Karnsakul   +3 more
doaj   +1 more source

Drug‐induced liver injury in a Swedish University hospital out‐patient hepatology clinic [PDF]

, 2006
M Valle, V. AV KLINTEBERG, N. ALEM, Rolf Olsson, Einar S. Björnsson   +4 more
openalex   +1 more source