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Drug-Induced Liver Injury and COVID-19 Infection: The Rules Remain the Same
Drug Safety, 2020 The pandemic infection by coronavirus 2019 (COVID-19) that spreading from China is generating a tremendous flow of information and one emerging point is the frequent association of COVID-19 infection with liver abnormalities. Studies from China showed an
A. Olry +5 more
semanticscholar +1 more source
Mechanisms of Drug-induced Liver Injury [PDF]
Clinics in Liver Disease, 2013 Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity.
Neil Kaplowitz, Liyun Yuan
openaire +2 more sources
COVID-19 and drug-induced liver injury: a problem of plenty or a petty point?
Archives of Toxicology, 2020 In December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in the Chinese province of Wuhan and rapidly infected hundreds of thousands of people worldwide.
J. Boeckmans +5 more
semanticscholar +1 more source
Medicine, 2011 Abstract Drug-induced liver injury (DILI) accounts for 9.5% of all suspected adverse drug reactions (ADRs) and for a significant proportion of fatal ADRs. DILI may be a direct toxic effect or an immunological reaction to either the drug or an active metabolite. Drugs can cause a diverse array of liver injury, which may be acute or chronic.
Alison M Brind +3 more
openaire +2 more sources
Stochastic Ordering under Conditional Modelling of Extreme Values: Drug-Induced Liver Injury [PDF]
arXiv, 2012 Drug-induced liver injury (DILI) is a major public health issue and of serious concern for the pharmaceutical industry. Early detection of signs of a drug's potential for DILI is vital for pharmaceutical companies' evaluation of new drugs. A combination of extreme values of liver specific variables indicate potential DILI (Hy's Law).
arxiv
Light chain systemic amyloidosis manifested as liver failure complicated with fatal spontaneous splenic rupture: A case report [PDF]
arXiv, 2021 For a patient with manifestations of nausea, abdominal distension, spontaneous splenic rupture, obvious liver enlargement, low red blood cells and platelets, yellow sclera, and spider angioma, Congo red staining of liver and spleen tissues indicated amyloidosis.
arxiv
CSH guidelines for the diagnosis and treatment of drug-induced liver injury
Hepatology International, 2017 Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health ...
Yuecheng Yu +35 more
semanticscholar +1 more source
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis
Cell Death and Disease, 2020 Drug-induced liver injury is the major cause of acute liver failure. However, the underlying mechanisms seem to be multifaceted and remain poorly understood, resulting in few effective therapies.
Min Wang +14 more
semanticscholar +1 more source
Shape Detection of Liver From 2D Ultrasound Images [PDF]
arXiv, 2019 Applications of ultrasound images have expanded from fetal imaging to abdominal and cardiac diagnosis. Liver-being the largest gland in the body and responsible for metabolic activities requires to be to be diagnosed and therefore subject to utmost injury. Although, ultrasound imaging has developed into three and four dimensions providing higher amount
arxiv
Annals of Hepatology, 2019 Introduction and aim: Epidemiological information regarding drug-induced liver injury in some Latin American countries remains limited. Therefore, disease prevention and health promotion strategies are imperative to reduce drug-induced liver injuries and
Alejandra Cano-Paniagua +3 more
doaj