Results 181 to 190 of about 26,575 (260)

Exploring drug-induced liver injury: comprehensive insights into mechanisms and management of hepatotoxic agents

Future Journal of Pharmaceutical Sciences
Background Drug-induced liver injury (DILI) is a significant adverse drug reaction, manifesting through a range of clinical presentations from mild liver enzyme to acute liver failure.
Ahmed K. Saleh, Thanaa A. El-Masry, Aya H. El-Kadem, Nada A. Ashour, Nageh A. El-Mahdy   +4 more
doaj   +1 more source

Puromycin selection of cells with a high expression of the cytochrome P450 CYP3A4 gene activity from a patient with drug-induced liver injury (DILI) and their lifespan prolongation using a combination of CDK4^R24C, cyclin D1 and TERT

, 2020
Shoko Miyata, Noriaki Saku, Palaksha Kanive Javaregowda, Kenta Ite, Masashi Toyoda, Tōru Kimura, Hiroshi Nishina, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Tohru Kiyono, Akihiro Umezawa   +11 more
openalex   +1 more source

Global research trends of drug-induced liver injury (DILI) in the past two decades: a bibliometric and visualized study [PDF]

, 2021
Dan Liang, Yanping Guan, Jianhong Zhu, Junyan Wu, Xiaoxia Yu, Kaifeng Qiu, Zhichao He, Qing He   +7 more
openalex   +1 more source

Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI). [PDF]

PLoS Comput Biol, 2022
Liu A, Han N, Munoz-Muriedas J, Bender A.   +3 more
europepmc   +1 more source

A Novel Computer-Assisted Drug-Induced Liver Injury Causality Assessment Tool (DILI-CAT) [PDF]

, 2021
Hans L. Tillmann, Ayako Suzuki, Michael Merz, Richard Hermann, Don C. Rockey   +4 more
openalex   +1 more source

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET] [PDF]

, 2021
José C. Fernández-Checa, Pierre Bagnaninchi, Hui Ye, Pau Sancho–Bru, Juan Manuel Falcón‐Pérez, Félix Royo, Carmen García‐Ruiz, Özlen Konu, Joana P. Miranda, Oleg Lunov, A. Dejneka, Alistair Elfick, Alison McDonald, Gareth J. Sullivan, Guruprasad P. Aithal, M. Isabel Lucena, Raúl J. Andrade, Bernard Fromenty, Michel Kranendonk, Francisco Javier Cubero, Leonard J. Nelson   +20 more
openalex   +1 more source

Hepatotoxicity associated with statins: A retrospective pharmacovigilance study based on the FAERS database.

PLoS ONE
BackgroundStatins are commonly prescribed in clinical practice and are associated with a high risk of drug-induced liver injury (DILI). This study aims to examine the real-world data on statin-induced liver injury to assess medication safety.MethodsAll ...
Lu Zhou, Bin Wu, Yuan Bian, Yun Lu, Ya Zou, Shanshan Lin, Qinchuan Li, Chun Liu   +7 more
doaj   +1 more source

A new framework for advancing in drug‐induced liver injury research. The Prospective European DILI Registry [PDF]

, 2022
Einar S. Björnsson, Camilla Stephens, Edmond Atallah, Mercedes Robles‐Díaz, Ismael Álvarez‐Álvarez, Alexander L. Gerbes, Sabine Weber, Guido Stirnimann, Gerd A. Kullak‐Ublick, Helena Cortez‐Pinto, Jane I. Grove, M. Isabel Lucena, Raúl J. Andrade, Guruprasad P. Aithal   +13 more
openalex   +1 more source

Integrating adverse outcome pathways (AOPs) and high throughput in vitro assays for better risk evaluations, a study with drug-induced liver injury (DILI)_suppl

, 2019
Kapil Khadka
openalex   +2 more sources

Survival regression by data fusion [PDF]

, 2014
Any knowledge discovery could in principal benefit from the fusion of directly or even indirectly related data sources. In this paper we explore whether data fusion by simultaneous matrix factorization could be adapted for survival regression. We propose
Zitnik, Marinka, Zupan, Blaz
core