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Role of immune reactions in drug-induced liver injury (DILI)
Drug Metabolism Reviews, 2012Although some drugs cause drug-induced liver injury (DILI) through direct damage to hepatocytes or intereference with bile secretion, others cause delayed, often idiosyncratic, DILI with clinical features, such as mild lymphocytic infiltrate, that are reminiscent of allergic reactions involving activation of the adaptive immune system. Even in cases of
Cynthia, Ju, Timothy, Reilly
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Global Epidemiology of Drug-Induced Liver Injury (DILI)
Current Hepatology Reports, 2019Drug-induced liver injury (DILI) is not an uncommon liver disease in many parts of the world. DILI is one of the most common causes of acute liver failure in most countries. The current review summarizes the global epidemiology of DILI. The number need to harm in terms of DILI due to amoxicillin-clavulanate was approximately 1 out 2300, but was higher ...
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Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment
Annals of Pharmacotherapy, 2019Background: Micafungin is increasingly used in the treatment and prevention of candidiasis in hospitalized patients. Limited data are available from which to assess the risk of drug-induced liver injury (DILI) with micafungin. No studies, to date, have applied a standardized causality assessment method to the study of micafungin-associated DILI ...
Caitlin Mullins +2 more
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Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies
Journal of Medicinal Chemistry, 2020Adverse drug reactions (ADRs) are a common cause of attrition in drug discovery and development and drug-induced liver injury (DILI) is a leading cause of preclinical and clinical drug terminations. This perspective outlines many of the known DILI mechanisms and assessment methods used to evaluate and mitigate DILI risk.
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Role of Genetic Polymorphisms in Drug-Induced Liver Injury (DILI)
Journal of Pharmacology, Genetics and Molecular BiologyA major cause of acute liver failure and drug reaction, drug induced liver injury (DILI) usually has a genetic component. This paper discusses the effect of genetic polymorphisms as a risk factor of DILI with reference to different inbred and genetically altered mouse models.
Srikumar Chakravarthi +4 more
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WHY TARGET AYURVEDIC DRUGS FOR DRUG INDUCED LIVER INJURY (DILI)?
INDIAN DRUGSDear Reader, Use of herbs as medicines is as old as history of human civilization. Discovery of most of the modern medicines dates back to 19th and 20th century. Most of the potent drugs discovered have their origin in plants and they were also called “Drugs from Plants or Drugs from Nature”.
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DRUG-INDUCED LIVER INJURY-DILI AND HILI IN CLINICAL PRACTICE
Drug-induced liver damage is still a problem for modern medicine. On the one hand, it is related tothe polyprogression found mainly in the elderly and chronically ill, and on the other hand, to thefashion for young people to use dietary supplements and herbs. The course of DILI can range froma mild, asymptomatic, reversible increase in liver parametersRajewski, Paweł +2 more
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Steatosis as risk factor for drug-induced liver injury (DILI)
Toxicology Letters, 2021R. Kostadinova +5 more
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Pulmonary Tuberculosis with Pneumonia, Pneumoconiosis, and Drug Induced Liver Injury (DILI)
Lombok Medical JournalTuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. According to the World Health Organization (WHO), TB is one of the top 10 causes of death in the world. TB is divided into pulmonary TB and extrapulmonary TB. Extra-pulmonary TB is defined as TB involving organs other than the lungs (pleura, lymph nodes, abdomen, skin ...
Ni Kadek Mega Suryantini +3 more
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