Results 221 to 230 of about 26,575 (260)
Acute Hepatitis in a Patient Treated With Ribociclib for Metastatic Breast Carcinoma. [PDF]
J Med CasesIguh C, Bakhsh I, Grujic S.
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Computed tomography manifestations of drug-induced liver injury according to type and severity of injury. [PDF]
Quant Imaging Med SurgChen Y +7 more
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Letter to the Editor: Fimasartan-Induced Liver Injury and Update on Hepatotoxicity Risks. [PDF]
J Korean Med SciLee J, Chin S, Kim SG, Kim YS, Yoo JJ.
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Influence of metabolic dysfunction-associated steatotic liver disease on antituberculosis drug-induced liver injury. [PDF]
Medicine (Baltimore)Shen Y, Liu J.
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Journal of Medicinal Chemistry, 2020
Adverse drug reactions (ADRs) are a common cause of attrition in drug discovery and development and drug-induced liver injury (DILI) is a leading cause of preclinical and clinical drug terminations.
B. Norman
semanticscholar +4 more sources
Adverse drug reactions (ADRs) are a common cause of attrition in drug discovery and development and drug-induced liver injury (DILI) is a leading cause of preclinical and clinical drug terminations.
B. Norman
semanticscholar +4 more sources
Role of immune reactions in drug-induced liver injury (DILI)
Drug Metabolism Reviews, 2012Although some drugs cause drug-induced liver injury (DILI) through direct damage to hepatocytes or intereference with bile secretion, others cause delayed, often idiosyncratic, DILI with clinical features, such as mild lymphocytic infiltrate, that are reminiscent of allergic reactions involving activation of the adaptive immune system. Even in cases of
C. Ju, T. Reilly
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The rediscovery of HepG2 cells for prediction of drug induced liver injury (DILI)
EXCLI journal, 2014 EXCLI Journal ; Vol.
A. Ghallab
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Drug Safety, 2016
The relationship between drugs and pre-existing liver disease is complex, particularly when increased liver tests (LTs) or new symptoms emerge in patients with pre-existing liver disease during drug therapy. This requires two strategies to assess whether these changes are due to drug-induced liver injury (DILI) as a new event or due to flares of the ...
R. Teschke, G. Danan
semanticscholar +4 more sources
The relationship between drugs and pre-existing liver disease is complex, particularly when increased liver tests (LTs) or new symptoms emerge in patients with pre-existing liver disease during drug therapy. This requires two strategies to assess whether these changes are due to drug-induced liver injury (DILI) as a new event or due to flares of the ...
R. Teschke, G. Danan
semanticscholar +4 more sources
Critical Reviews in Toxicology, 2017
Drug-induced liver injury (DILI) is a major safety issue during drug development, as well as the most common cause for the withdrawal of drugs from the pharmaceutical market. The identification of DILI biomarkers is a labor-intensive area. Conventional biomarkers are not specific and often only appear at significant levels when liver damage is ...
A. M. Araújo +4 more
semanticscholar +5 more sources
Drug-induced liver injury (DILI) is a major safety issue during drug development, as well as the most common cause for the withdrawal of drugs from the pharmaceutical market. The identification of DILI biomarkers is a labor-intensive area. Conventional biomarkers are not specific and often only appear at significant levels when liver damage is ...
A. M. Araújo +4 more
semanticscholar +5 more sources