Results 231 to 240 of about 12,201 (250)

Clinical features and prognosis of drug-induced liver injury in patients with non-alcoholic fatty liver. [PDF]

World J Hepatol
Zhao Y, Li JZ, Liu YG, Zhu YJ, Zhang Y, Zheng WW, Ma L, Li J, Wang CY.   +8 more
europepmc   +1 more source

Drug-Induced Liver Injury-Pharmacological Spectrum Among Children. [PDF]

Int J Mol Sci
Maris BR, Grama A, Pop TL.
europepmc   +1 more source

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Role of immune reactions in drug-induced liver injury (DILI)

Drug Metabolism Reviews, 2012
Although some drugs cause drug-induced liver injury (DILI) through direct damage to hepatocytes or intereference with bile secretion, others cause delayed, often idiosyncratic, DILI with clinical features, such as mild lymphocytic infiltrate, that are reminiscent of allergic reactions involving activation of the adaptive immune system. Even in cases of
Timothy P. Reilly, Changqing Ju
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Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment

Annals of Pharmacotherapy, 2019
Background: Micafungin is increasingly used in the treatment and prevention of candidiasis in hospitalized patients. Limited data are available from which to assess the risk of drug-induced liver injury (DILI) with micafungin. No studies, to date, have applied a standardized causality assessment method to the study of micafungin-associated DILI ...
Caitlin Mullins, Kirthana Beaulac, Lynne Sylvia   +2 more
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Arzneimittel als Auslöser von Leberschäden [PDF]

MMW - Fortschritte der Medizin, 2019
Medikamenten-induzierte Leberschaden (Drug-induced liver injuries, DILI) fuhren zunachst zu auffalligen Leberparametern. Sie sind zwar selten, in den USA und Europa aber die haufigste Ursache fur das akute Leberversagen. Daher stellen sie eine wichtige Differenzialdiagnose dar. Der Hausarzt muss v. a. bei der Anamnese grundlich vorgehen.
openaire   +2 more sources

Global Epidemiology of Drug-Induced Liver Injury (DILI)

Current Hepatology Reports, 2019
Drug-induced liver injury (DILI) is not an uncommon liver disease in many parts of the world. DILI is one of the most common causes of acute liver failure in most countries. The current review summarizes the global epidemiology of DILI. The number need to harm in terms of DILI due to amoxicillin-clavulanate was approximately 1 out 2300, but was higher ...
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Metabolomic approaches in the discovery of potential urinary biomarkers of drug-induced liver injury (DILI)

Critical Reviews in Toxicology, 2017
Drug-induced liver injury (DILI) is a major safety issue during drug development, as well as the most common cause for the withdrawal of drugs from the pharmaceutical market. The identification of DILI biomarkers is a labor-intensive area. Conventional biomarkers are not specific and often only appear at significant levels when liver damage is ...
Araújo, Ana Margarida, Carvalho, Márcia, Carvalho, Félix, Bastos, Maria de Lourdes, Guedes de Pinho, Paula   +4 more
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Diagnosis and Management of Drug-Induced Liver Injury (DILI) in Patients with Pre-Existing Liver Disease

Drug Safety, 2016
The relationship between drugs and pre-existing liver disease is complex, particularly when increased liver tests (LTs) or new symptoms emerge in patients with pre-existing liver disease during drug therapy. This requires two strategies to assess whether these changes are due to drug-induced liver injury (DILI) as a new event or due to flares of the ...
Gaby Danan, Rolf Teschke
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DRUG-INDUCED LIVER INJURY-DILI AND HILI IN CLINICAL PRACTICE

Drug-induced liver damage is still a problem for modern medicine. On the one hand, it is related tothe polyprogression found mainly in the elderly and chronically ill, and on the other hand, to thefashion for young people to use dietary supplements and herbs. The course of DILI can range froma mild, asymptomatic, reversible increase in liver parameters
Rajewski, Paweł, Jakub, Cieściński, Piotr, Rajewski   +2 more
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Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies

Journal of Medicinal Chemistry, 2020
Adverse drug reactions (ADRs) are a common cause of attrition in drug discovery and development and drug-induced liver injury (DILI) is a leading cause of preclinical and clinical drug terminations. This perspective outlines many of the known DILI mechanisms and assessment methods used to evaluate and mitigate DILI risk.
openaire   +3 more sources