Results 181 to 190 of about 1,381,560 (302)

Drug-likeness prioritised selection identifies anti-<i>Escherichia coli</i> candidates confirmed by molecular docking, dynamics simulations, and antibacterial assays. [PDF]

J Enzyme Inhib Med Chem
Yu B, Zhu H, Xu L, Zhao X, Shi W.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

AI-driven <i>de novo</i> design of BRAF inhibitors with enhanced binding affinity and optimized drug-likeness. [PDF]

PeerJ
Lu Z, Zhang A.
europepmc   +1 more source

miDruglikeness: Subdivisional Drug-Likeness Prediction Models Using Active Ensemble Learning Strategies. [PDF]

Biomolecules, 2022
Cai C, Lin H, Wang H, Xu Y, Ouyang Q, Lai L, Pei J.   +6 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Introduction to drug utilization research

, 2003
Prepared by the WHO Collaborating Centre for Drug Statistics Methodology, the WHO Collaborating Centre for Drug Utilization Research and Clinical Pharmacological Services, and the International Working Group for Drug Statistics Methodology48 p.Korean ...
WHO International Working Group for Drug Statistics Methodology, WHO Collaborating Centre for Drug Statistics Methodology, WHO Collaborating Centre for Drug Utilization Research and Clinical Pharmacological Services   +2 more
core   +1 more source

Eco-friendly synthesis of an antimicrobial polymer (1,4-bis(methacryloyl)piperazine) via maghnite catalysis: <i>in vitro</i> activity and <i>in silico</i> drug-likeness. [PDF]

Front Chem
Derkaoui S, Boudou F, Keziz A, Berkane A, Alsaeedi H, Cornu D, Bechelany M, Barhoum A.   +7 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Comprehensive Characterization of <i>Lantana camara</i> Essential Oil from Angola: GC-MS Profiling, Antioxidant Capacity, and Drug-likeness Prediction. [PDF]

Antioxidants (Basel)
Kinkela N, Morales A, Sánchez-Martínez HA, Díaz M, Samba N, Mawunu M, Morán-Pinzón JA, Silva L, Rodilla JM, Guerrero De León E.   +9 more
europepmc   +1 more source

In silico Study of Antiviral Activity of Polyphenol Compounds from Ocimum basilicum by Molecular Docking, ADMET, and Drug-Likeness Analysis. [PDF]

Adv Appl Bioinform Chem, 2023
Kurnia D, Putri SA, Tumilaar SG, Zainuddin A, Dharsono HDA, Amin MF.   +5 more
europepmc   +1 more source