Pharmacokinetics and Toxicity Overview of Active Compounds Berberine, Palmatine, and Jatrorrhizine From Fibraurea tinctoria Lour: Drug-Likeness, ADMET Prediction, and In Vivo Extract Toxicity Assessment [PDF]
Journal of ToxicologyFibraurea tinctoria Lour has long been used by the indigenous ethnic groups of Kalimantan in the traditional treatment of malaria, jaundice, and diabetes mellitus.
Indah Purwaningsih +3 more
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Current Trends and Challenges in Drug-Likeness Prediction: Are They Generalizable and Interpretable?
Health Data Science, 2023 Importance: Drug-likeness of a compound is an overall assessment of its potential to succeed in clinical trials, and is essential for economizing research expenditures by filtering compounds with unfavorable properties and poor development potential.
Wenyu Zhu +4 more
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Not Drug-like, but Like Drugs: Cnidaria Natural Products
Marine Drugs, 2021 Phylum Cnidaria has been an excellent source of natural products, with thousands of metabolites identified. Many of these have not been screened in bioassays.
Claire Laguionie-Marchais +11 more
doaj +1 more source
Prediction of Drug-likeness of Central Nervous System Drug Candidates Using a Feed-Forward Neural Network Based on Chemical Structure [PDF]
, 2020 Modern medical science has been greatly advanced by the development of new drugs, despite the fact that the process of developing new drugs is costly and time-consuming.
Xiao, Wang, Yi-Gao, Yuan
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Historeceptomic Fingerprints for Drug-Like Compounds [PDF]
Frontiers in Physiology, 2015 Most drugs exert their beneficial and adverse effects through their combined action on several different molecular targets (polypharmacology). The true molecular fingerprint of the direct action of a drug has two components: the ensemble of all the receptors upon which a drug acts and their level of expression in organs/tissues.
Evgeny eShmelkov +7 more
openaire +3 more sources
Frontiers in Cellular and Infection Microbiology, 2023 Tick-borne Babesiosis is a parasitic infection caused by Babesia microti that can infect both animals and humans and may spread by tick, blood transfusions, and organ transplantation. The current therapeutic options for B.
Shopnil Akash +11 more
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Natural flavonoids in Delonix regia leaf as an antimycobacterial agent: An in silico study [PDF]
Journal of the Serbian Chemical Society, 2023 Multi-drug resistant (MDR) and extensively-drug resistant (XDR) as results of continuous use of antibiotics encourage the development of new antimycobacterial drugs.
Tjitda Putra Jiwamurwa Pama +3 more
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Drug Likeness Screening of Black Soybean Flavonoids
, 2023 Screening of drug-likeness and toxicity of compounds contained in black soybeans. A) Screening for drug-likeness, B) Toxicity screening, C) 2D structure of compounds that pass the screening.
Ricadonna Raissa (12081878) +1 more
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The drug likeness analysis of anti-inflammatory clerodane diterpenoids
Chinese Medicine, 2020 Inflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders.
Zheling Feng +3 more
doaj +1 more source
Novel QSAR methods to permit drug-likeness profiling.
, 2004 Novel QSAR methods to permit drug-likeness ...
Dahua. Pan (7967639)
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