Results 41 to 50 of about 1,381,560 (302)

Predicted drug-likeness and toxicity properties of Salvia fruticosa compounds

, 2023
The datasets present computationally predicted drug-likeness and toxicity profiles of Salvia frutocosa ...
Farirai Mandivenga, Ryman Shoko
core   +1 more source

Effect of Date Palm (Phoenix dactylifera) Phytochemicals on Aβ1−40 Amyloid Formation: An in-silico Analysis

Frontiers in Neuroscience, 2022
Alzheimer's disease (AD) is a neurodegenerative disease and the most prevalent form of dementia. The generation of oxygen free radicals and oxidative damage is believed to be involved in the pathogenesis of AD.
Qamar Zia, Qamar Zia, Md Tabish Rehman, Md Amiruddin Hashmi, Sahabjada Siddiqui, Abdulaziz Bin Dukhyil, Mohammad Z. Ahmed, Azfar Jamal, Azfar Jamal, Saeed Banawas, Saeed Banawas, Saeed Banawas, Sami G. Almalki, Mohammad Owais, Hamad Qasem Aldhafeeri, Ibrahim M. Ibrahim, Wael Alturaiki, Mohamed F. AlAjmi, Mohammed Alsieni, Yaser E. Alqurashi   +19 more
doaj   +1 more source

β-Aminopropioamidoximes derivatives as potential antitubercular agents against anthropozoonotic infections caused by Mycobacterium tuberculosis and Mycobacterium bovis [PDF]

Veterinary World
Background and Aim: Tuberculosis (TB) remains a significant global health challenge, with increasing incidences of drug-sensitive (DS) and multidrug-resistant (MDR) TB.
Lyudmila Kayukova, Venera Bismilda, Kairat Turgenbayev, Asem Uzakova, Gulnur Baitursynova, Umirzak Jussipbekov, Meruyert Mukanova, Lyailya Chingissova, Gulnur Dyussembayeva, Assiya Borsynbayeva, Azamat Yerlanuly, Ablay Auyezov   +11 more
doaj   +1 more source

Pharmacokinetic properties of 125 carotenoids with appropriate drug-likeness property.

, 2022
Pharmacokinetic properties of 125 carotenoids with appropriate drug-likeness property.
Mohammad Ali Amoozegar (2370607), Farzaneh Taghipour (14304933), Nasrin Motamed (2294488), Soodeh Mahdian (14304936), Maryam Shahhoseini (2007535)   +4 more
core   +1 more source

Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites

Frontiers in Pharmacology, 2015
Background. A recent comparison showed the extensive similarities between the structural properties of metabolites in the reconstructed human metabolic network (‘endogenites’) and those of successful, marketed drugs (‘drugs’). Results.
Steve eO'Hagan, Douglas Bruce Kell
doaj   +1 more source

New Synthetic Methodology for Drug-like Molecules

Molecules, 2023
The field of synthetic methodology plays a pivotal role in the quest for safe and effective drugs [...]
Rapposelli, Simona, Barker, Graeme, Graeme Barker, Simona Rapposelli   +3 more
openaire   +4 more sources

In Silico Evaluation of Pharmacokinetics and Toxicity Profile of AlkaloidsPresent in Leaves of Catharanthus roseus L.

RGUHS Journal of Pharmaceutical Sciences
Background Catharanthus roseus Madagascar periwinkle is a well-known medicinal plant that produces a variety of alkaloids with significant pharmacological activities particularly in cancer and diabetes treatment.Aim This study aimed ...
Ramgopal M Dhanwad, Usha R, Ganesh S
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

A physicochemical descriptor-based scoring scheme for effective and rapid filtering of kinase-like chemical space

Journal of Cheminformatics, 2012
Background The current chemical space of known small molecules is estimated to exceed 1060 structures. Though the largest physical compound repositories contain only a few tens of millions of unique compounds, virtual screening of databases of this size ...
Singh Narender, Sun Hongmao, Chaudhury Sidhartha, AbdulHameed Mohamed, Wallqvist Anders, Tawa Gregory   +5 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source