Results 51 to 60 of about 1,944,029 (193)

Physicochemical properties for drug-likeness.

, 2016
Physicochemical properties for drug-likeness.
Efeturi Abraham Onoabedje (3225060), Ufuoma Shalom Onoabedje (3225063), Akachukwu Ibezim (1747750), Uchechukwu Chris Okoro (3225057), Sunday Nwankwor Okafor (3225066)   +4 more
core   +1 more source

Development of a new drug candidate for the inhibition of Lassa virus glycoprotein and nucleoprotein by modification of evodiamine as promising therapeutic agents

Frontiers in Microbiology, 2023
The Lassa virus (LASV), an RNA virus prevalent in West and Central Africa, causes severe hemorrhagic fever with a high fatality rate. However, no FDA-approved treatments or vaccines exist.
Shopnil Akash, Javiera Baeza, Javiera Baeza, Sajjat Mahmood, Nobendu Mukerjee, Nobendu Mukerjee, Vetriselvan Subramaniyan, Vetriselvan Subramaniyan, Md. Rezaul Islam, Gaurav Gupta, Gaurav Gupta, Vinibha Rajakumari, Suresh V. Chinni, Suresh V. Chinni, Gobinath Ramachawolran, Fayez M. Saleh, Ghadeer M. Albadrani, Amany A. Sayed, Mohamed M. Abdel-Daim, Mohamed M. Abdel-Daim   +19 more
doaj   +1 more source

New Synthetic Methodology for Drug-like Molecules

Molecules, 2023
The field of synthetic methodology plays a pivotal role in the quest for safe and effective drugs [...]
Rapposelli, Simona, Barker, Graeme, Graeme Barker, Simona Rapposelli   +3 more
openaire   +4 more sources

In Silico Evaluation of Pharmacokinetics and Toxicity Profile of AlkaloidsPresent in Leaves of Catharanthus roseus L.

RGUHS Journal of Pharmaceutical Sciences
Background Catharanthus roseus Madagascar periwinkle is a well-known medicinal plant that produces a variety of alkaloids with significant pharmacological activities particularly in cancer and diabetes treatment.Aim This study aimed ...
Ramgopal M Dhanwad, Usha R, Ganesh S
doaj   +1 more source

Effect of Date Palm (Phoenix dactylifera) Phytochemicals on Aβ1−40 Amyloid Formation: An in-silico Analysis

Frontiers in Neuroscience, 2022
Alzheimer's disease (AD) is a neurodegenerative disease and the most prevalent form of dementia. The generation of oxygen free radicals and oxidative damage is believed to be involved in the pathogenesis of AD.
Qamar Zia, Qamar Zia, Md Tabish Rehman, Md Amiruddin Hashmi, Sahabjada Siddiqui, Abdulaziz Bin Dukhyil, Mohammad Z. Ahmed, Azfar Jamal, Azfar Jamal, Saeed Banawas, Saeed Banawas, Saeed Banawas, Sami G. Almalki, Mohammad Owais, Hamad Qasem Aldhafeeri, Ibrahim M. Ibrahim, Wael Alturaiki, Mohamed F. AlAjmi, Mohammed Alsieni, Yaser E. Alqurashi   +19 more
doaj   +1 more source

Descriptors, Physical Properties, and Drug-Likeness

, 2016
We have investigated techniques for distinguishing between drugs and nondrugs using a set of molecular descriptors derived from semiempirical molecular orbital (AM1) calculations.
Bernd Beck (2310691), Timothy Mitchell (40096), William King (3013917), Timothy Clark (425636), Torsten Schindler (3013920), Matthias Brüstle (3013923)   +5 more
core   +1 more source

The Beekeeping Sector of Kazakhstan and Contributions to the Pharmaceutical Industry: Promising Flavonoids with the Pharmacokinetic Properties Via the Computational Evaluations [version 2; peer review: 2 approved]

F1000Research
Background Bee products are rich sources of bioactive flavonoids with potential applications in nutraceutical and pharmaceutical research. However, differences in the physicochemical and pharmacokinetic properties of individual flavonoids may ...
Şeyda Kaya, Tulkinzhon Gaipov, Taner Daştan, Zeliha Selamoglu, Nurdana Salybekova, Sevgi Durna Daştan   +5 more
doaj   +1 more source

β-Aminopropioamidoximes derivatives as potential antitubercular agents against anthropozoonotic infections caused by Mycobacterium tuberculosis and Mycobacterium bovis [PDF]

Veterinary World
Background and Aim: Tuberculosis (TB) remains a significant global health challenge, with increasing incidences of drug-sensitive (DS) and multidrug-resistant (MDR) TB.
Lyudmila Kayukova, Venera Bismilda, Kairat Turgenbayev, Asem Uzakova, Gulnur Baitursynova, Umirzak Jussipbekov, Meruyert Mukanova, Lyailya Chingissova, Gulnur Dyussembayeva, Assiya Borsynbayeva, Azamat Yerlanuly, Ablay Auyezov   +11 more
doaj   +1 more source

In silico identification of natural compounds against SARS-CoV-2 main protease from Chinese herbal medicines

Future Science OA, 2023
Aim: To determine natural compounds with inhibitory effects toward SARS-CoV-2 Mpro from Chinese herbal medicines. Materials & methods: ∼1200 natural compounds from 19 Chinese herbal medicines were collected.
Yi Kuang, Wenjing Shen, Xiaodong Ma, Ziwei Wang, Rui Xu, Qingqing Rao, Shengxiang Yang   +6 more
doaj   +1 more source

Toward Drug-Like Multispecific Antibodies by Design [PDF]

International Journal of Molecular Sciences, 2020
The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions.
Sawant, Manali S., Streu, Craig N., Wu, Lina, Tessier, Peter M.   +3 more
openaire   +2 more sources