Results 31 to 40 of about 27,071 (245)

Synthesis, in vitro antifungal evaluation and in silico study of 3-azolyl-4-chromanone phenylhydrazones [PDF]

, 2012
BACKGROUND: The currently available antifungal drugs suffer from toxicity, greatest potential drug interactions with other drugs, insufficient pharmacokinetics properties, and development of resistance.
Adile Ayati, Hamid Irannejad, Mehraban Falahati, Saeed Emami   +3 more
core   +1 more source

Challenging the Drug-Likeness Dogma for New Drug Discovery in Tuberculosis

Frontiers in Microbiology, 2018
The emergence of multi- and extensively drug resistant tuberculosis worldwide poses a great threat to human health and highlight the need to discover and develop new, effective and inexpensive antituberculosis agents.
Diana Machado, Miriam Girardini, Miguel Viveiros, Marco Pieroni   +3 more
doaj   +1 more source

Biofilm reduction, in-vitro cytotoxicity and computational drug-likeness of selected phytochemicals to combat multidrug-resistant bacteria

Scientific African, 2023
Multidrug-resistant (MDR) bacteria in biofilms are frequently linked with persistent infections across healthcare settings, due to their virulence factors.
Itumeleng T. Baloyi, Idowu J. Adeosun, Francesca Bonvicini, Sekelwa Cosa   +3 more
doaj   +1 more source

Virtual dual inhibition of COX-2 / 5-LOX enzymes based on binding properties of alpha-amyrins, the anti-inflammatory compound as a promising anti-cancer drug [PDF]

, 2016
Hydro-alcoholic fruit extract of Cordia myxa was considerably effective on curing acute inflammation in mouse model. Previous studies suggested significant anti-inflammatory activities as well as potential anticancer agent of α-amyrins in seeds ...
Assadolahi, Vahideh, Nikaein, Donya, Ranjbar, Mohammad Mehdi, Rashidieh, Behnam, Yazdani, Mohsen   +4 more
core   +1 more source

Multifunctional effect of flavonoids from Millettia brandisiana against Alzheimer's disease pathogenesis

Heliyon, 2023
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and neuronal death. Fifteen flavonoids from Millettia brandisiana were evaluated for the multifunctional effect against AD pathogenesis, including ...
Puguh Novi Arsito, Pornthip Waiwut, Chavi Yenjai, Supakorn Arthan, Orawan Monthakantirat, Natsajee Nualkaew, Pitchayakarn Takomthong, Chantana Boonyarat   +7 more
doaj   +1 more source

Molecular docking studies, drug-likeness and in-silico ADMET prediction of some novel β-Amino alcohol grafted 1,4,5-trisubstituted 1,2,3-triazoles derivatives as elevators of p53 protein levels

Scientific African, 2020
Malaria is a killer disease caused by Plasmodium falciparum and is responsible for over a million death annually. Chloroquine, quinine, pyrimethamine, proguanil, artemisinin, atovaquone, and mefloquine are different kinds of drugs employed to treat the ...
Zakari Ya'u Ibrahim, Adamu Uzairu, Gideon Shallangwa, Stephen Abechi   +3 more
doaj   +1 more source

In silico pharmacokinetic and toxicological properties prediction of bioactive compounds from Andrographis paniculata

National Journal of Physiology, Pharmacy and Pharmacology, 2020
Background: Andrographis paniculata used in Siddha system of medicine as nilavembu. The scientific rationale and possible pharmacokinetic and toxicological profile of ingredients responsible for the activity are yet to be explored.
Subash K R
doaj   +1 more source

Development of a new drug candidate for the inhibition of Lassa virus glycoprotein and nucleoprotein by modification of evodiamine as promising therapeutic agents

Frontiers in Microbiology, 2023
The Lassa virus (LASV), an RNA virus prevalent in West and Central Africa, causes severe hemorrhagic fever with a high fatality rate. However, no FDA-approved treatments or vaccines exist.
Shopnil Akash, Javiera Baeza, Javiera Baeza, Sajjat Mahmood, Nobendu Mukerjee, Nobendu Mukerjee, Vetriselvan Subramaniyan, Vetriselvan Subramaniyan, Md. Rezaul Islam, Gaurav Gupta, Gaurav Gupta, Vinibha Rajakumari, Suresh V. Chinni, Suresh V. Chinni, Gobinath Ramachawolran, Fayez M. Saleh, Ghadeer M. Albadrani, Amany A. Sayed, Mohamed M. Abdel-Daim, Mohamed M. Abdel-Daim   +19 more
doaj   +1 more source

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V., Brindley, Paul J., Bulman, Christina A., Elfawal, Mostafa A., Helander, Jon, Janetka, James W., Mitreva, Makedonka, Rosa, Bruce A., Sakanari, Judy, Tyagi, Rahul, Wildman, Scott A.   +10 more
core   +3 more sources

In silico identification of natural compounds against SARS-CoV-2 main protease from Chinese herbal medicines

Future Science OA, 2023
Aim: To determine natural compounds with inhibitory effects toward SARS-CoV-2 Mpro from Chinese herbal medicines. Materials & methods: ∼1200 natural compounds from 19 Chinese herbal medicines were collected.
Yi Kuang, Wenjing Shen, Xiaodong Ma, Ziwei Wang, Rui Xu, Qingqing Rao, Shengxiang Yang   +6 more
doaj   +1 more source