Results 31 to 40 of about 523,570 (260)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Study of Knowledge and Drug Related Problems of Warfarin at Outpatient Vachiraphuket Hospital

Journal of Health Science and Medical Research (JHSMR), 2015
Objective: The objectives of this study were to evaluate a knowledge of warfarin, type and number of drug related problems (DRPs) by pharmacists at outpatient department of Vachiraphuket Hospital.
Apichat Jittsue, Suwimon Yeephu, Tulaya Potaros, Juntarus Sekkhunthod, Phiyanuch Timkorn   +4 more
doaj  

Drug related problems in older adults living with dementia.

PLoS ONE, 2020
BackgroundCompared with those without dementia, older patients with dementia admitted to acute care settings are at higher risk for triad combination of polypharmacy (PP), potentially inappropriate medication (PIM), and drug-drug interaction (DDI), which
Sirasa Ruangritchankul, Nancye M Peel, Leila Shafiee Hanjani, Leonard C Gray   +3 more
doaj   +1 more source

Correlation between geriatric ischemic stroke patient characeteristic and drug related problems

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2020
Background: Drug related problems (DRP) can cause problems in treatments of patients with ischemic stroke. Objective: This study was to determine the correlation between the characteristics of patients with ischemic stroke and the DRP.
Dhanang Prawira Nugraha, Antonius Adji Prayitno Setiadi, Yosi Irawati Wibowo   +2 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Need of advance clinical pharmacy services: A case study from Pakistan

Archives of Pharmacy Practice, 2015
Clinical pharmacists play a key role in health-care by providing drug information to other health-care professionals, pharmaceutical care to individual patients and developing clinical guidelines and standard treatment protocols for treating various ...
Iftikhar Ali, Jehanzeb Khan, Aziz Ullah Khan   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Alcohol‐ and drug‐related absenteeism: a costly problem

Australian and New Zealand Journal of Public Health, 2016
Absenteeism related to alcohol and other drug (AOD) use can place a substantial burden on businesses and society. This study estimated the cost of AOD-related absenteeism in Australia using a nationally representative dataset.A secondary analysis of the 2013 National Drug Strategy Household Survey (n=12,196) was undertaken.
Ann Roche, Ken Pidd, Victoria Kostadinov
openaire   +3 more sources