Results 31 to 40 of about 3,173 (215)

Drug related problems in older adults living with dementia.

PLoS ONE, 2020
BackgroundCompared with those without dementia, older patients with dementia admitted to acute care settings are at higher risk for triad combination of polypharmacy (PP), potentially inappropriate medication (PIM), and drug-drug interaction (DDI), which
Sirasa Ruangritchankul, Nancye M Peel, Leila Shafiee Hanjani, Leonard C Gray   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Minding the gap. Drug-related problems among breastfeeding women

Frontiers in Pharmacology
IntroductionDrug-related problems (DRPs) are a significant concern in many patient populations, including breastfeeding women. This study aimed to identify and characterize those problems in a group of breastfeeding women seeking specialized ...
Karolina Morze, Edyta Szałek, Magdalena Waszyk-Nowaczyk   +2 more
doaj   +1 more source

Alcohol‐ and drug‐related absenteeism: a costly problem

Australian and New Zealand Journal of Public Health, 2016
Absenteeism related to alcohol and other drug (AOD) use can place a substantial burden on businesses and society. This study estimated the cost of AOD-related absenteeism in Australia using a nationally representative dataset.A secondary analysis of the 2013 National Drug Strategy Household Survey (n=12,196) was undertaken.
Ann Roche, Ken Pidd, Victoria Kostadinov
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Negative Outcomes Associated with Medication in Neonates on Parenteral Nutrition Therapy

Pediatric Reports, 2023
Objective: In Ecuador, studies on clinical daily practice problems focused on parenteral nutrition in neonates are scarce. Therefore, this research aimed to identify negative results associated with medications (NRAM) in neonates with parenteral ...
Evelin Nataly Vega Díaz, Aida Adriana Miranda Barros, Monica Alexandra Castelo Reyna, Dennys Tenelanda López, Irvin Tubon   +4 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Prediction of drug-related problems in diabetic outpatients in a number of hospitals, using a modeling approach

Drug, Healthcare and Patient Safety, 2017
Ghaith M Al-Taani,1 Sayer I Al-Azzam,2 Karem H Alzoubi,2 Feras W Darwish Elhajji,3 Michael G Scott,4 Hamzah Alfahel,5 Mamoon A Aldeyab6 1Department of Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, 2Department of Clinical Pharmacy, Faculty ...
Al-Taani GM, Al-Azzam SI, Alzoubi KH, Darwish Elhajji FW, Scott MG, Alfahel H, Aldeyab MA   +6 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source