Results 61 to 70 of about 315,653 (264)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Patients’ Needs and Expectations for the Application of Prevention of Drug-related Problems Prevention Programs

Journal of Research in Pharmacy Practice
Objective: Drug-related problems (DRPs) constitute a relevant health issue with a significant and escalating impact. The objective of this study is to identify the needs and expectations of patients benefiting from secondary prevention programs for DRPs ...
Ainhoa Vilarrubias Llopis, Jesús Ruiz-Ramos, Adrián Plaza Díaz, Mireia Puig Campmany, Anna Buisan Álvarez, Caterina Sampol-Mayol, Ana Juanes-Borrego   +6 more
doaj   +1 more source

"Farmacogenetica quale strumento della farmacovigilanza per la predittività delle reazioni avverse da farmaci" [PDF]

, 2011
Senza dubbio le reazioni avverse da farmaci rappresentano un problema clinico rilevante, circa il 6,5% dei ricoveri ospedalieri è correlato con una reazione avversa.
BARNINI, BARBARA
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Perioperative and anesthetic deaths: toxicological and medico legal aspects [PDF]

, 2019
Background: Anesthesia has become safer during decades, though there is still a preventable mortality; the complexity of medical and surgical interventions, increasingly older and sicker patients, has created a host of new hazards in anesthesiology.
Argo A., Buscemi R., Karch S. B., Lanzarone A., Roccuzzo R., Zerbo S.   +5 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Prevalência e características dos eventos adversos a medicamentos no Brasil

Cadernos de Saúde Pública, 2018
Resumo: O presente trabalho tem como objetivo descrever a prevalência e fatores associados a eventos adversos a medicamentos (EAM) referidos por usuários de medicamentos no Brasil.
Livia Alves Oliveira de Sousa, Marta Maria de França Fonteles, Mirian Parente Monteiro, Sotero Serrate Mengue, Andréa Dâmaso Bertoldi, Tatiane da Silva Dal Pizzol, Noemia Urruth Leão Tavares, Maria Auxiliadora Oliveira, Vera Lucia Luiza, Luiz Roberto Ramos, Mareni Rocha Farias, Paulo Sergio Dourado Arrais   +11 more
doaj   +1 more source

Uncommon progression of toxoplasmic papillitis: patient perception and case report

Revista Brasileira de Oftalmologia, 2021
Ocular toxoplasmosis frequently presents as necrotizing retinochoroiditis and, less often, as peripapillary chorioretinitis and/or papillitis. The progression from papillitis to peripapillary retinochoroiditis has been rarely described.
Elcio Luiz Bonamigo, Eglas Emanuel Rossi, Maria do Carmo Nunes da Rosa, Ricardo Alexandre Stock, Rodrigo Rosa Sampaio, Ronei Carlos Lora   +5 more
doaj   +1 more source

Managing the Iatrogenic Risks of Risk Management [PDF]

, 1998
Analogizing to concerns that led the practice of medicine to shift from a specialist to a team-based approach, Dr. Wiener suggests that public and environmental health objectives would be better served if, e.g., regulatory jurisdiction were less ...
Wiener, Jonathan Baert
core   +2 more sources