Results 51 to 60 of about 315,653 (264)

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group. [PDF]

, 2017
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse ...
Abdallah, K., Anderson, J., Andrews, S., Arrindell, D., Ballesteros, J., Bingham, C. O., Boyer, J., Brogdon, C., Chen, D., Chonzi, D., Cotarla, I., Cunha, R., Dadu, R., Davies, M., Dawson, M., Diab, A., Dicker, Adam, Eifler, L., Ernstoff, M. S., Ferguson, A., Ferlini, C., Frankel, S., Go, W., Gochett, C., Goldberg, J., Goncalves, P., Goswami, T., Gregory, N., Gulley, J. L., Hamad, L., Hayreh, V., Helie, N., Holmes, W., Hsu, J. Y., Ibrahim, R., Kaufman, H. L., Kim, S., Lacouture, M. E., Lambotte, O., Larocca, C., LeBoeuf, N. R., Lehman, K., Lenihan, D., Ley-Acosta, S., Luke, J., McClure, J., Michelon, E., Nakamura, M., Onofrei, C., Patel, K., Piperdi, B., Puzanov, I., Rasheed, Z., Reshef, D., Riemer, J., Robert, C., Sarkeshik, M., Saylors, A., Schreiber, J., Shafer-Weaver, K., Shannon, V., Sharfman, W., Sharma, R., Sharon, E., Sherry, R., Silk, A. W., Simonson, C., Skondra, D., Suarez-Almazor, M. E., Thomas, C., Thompson, J. A., Trehu, E., Tresnan, D., Turner, M., Wang, Y., Wariabharaj, D., Waxman, I., Wiley, K., Wood, L., Zhang, L., Zheng, P.   +80 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sertraline induced severe neutropenia: An adolescent case with the Guillain-Barre syndrome (eng)

Klinik Psikiyatri Dergisi, 2021
Neutropenia, which is defined as a neutrophil count below 1500/ml, is a rare but potentially life-threatening side effect of psychotropic drugs.
Elif Akcay, Ozhan Yalcin
doaj   +1 more source

Mining Frequency of Drug Side Effects Over a Large Twitter Dataset Using Apache Spark [PDF]

, 2017
Despite clinical trials by pharmaceutical companies as well as current FDA reporting systems, there are still drug side effects that have not been caught. To find a larger sample of reports, a possible way is to mine online social media. With its current
Hsu, Dennis
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Side effects of chronic systemic glucocorticoid therapy: what dermatologists should know [PDF]

Anais Brasileiros de Dermatologia
In dermatologists' clinical practice, the use of systemic glucocorticoids is recurrent for the management of different comorbidities that require chronic immunosuppression. The prescription of this medication requires caution and basic clinical knowledge
Lucas Campos Prudente Tavares, Lívia de Vasconcelos Nasser Caetano, Mayra Ianhez   +2 more
doaj   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?

Clinics, 2018
OBJECTIVES: The aim of this study was to develop a strategy to identify adverse drug events associated with drug-drug interactions by analyzing the prescriptions of critically ill patients.
Grazielle Viana Ramos, André Miguel Japiassú, Fernando Augusto Bozza, Lusiele Guaraldo   +3 more
doaj   +1 more source

The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network [PDF]

, 2013
Background: Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients.
A Bashey, A Eckert, A Ribas, AA Sarnaik, Armin Justich, AV Maker, AV Maker, Axel Hauschild, Beatrice Schuler-Thurner, C Robert, Carmen Loquai, Carola Berking, Caroline J. Voskens, Caroline Robert, Christina Klein, Christine Mateus, Claus Garbe, Clemens L. Bockmeyer, Daniela Göppner, Dirk Schadendorf, F Bompaire, F Fadel, F Torino, FS Hodi, FS Hodi, G Berthod, G Borodic, G Graziani, G Graziani, G Hunter, G Hunter, Gerold Schuler, Gheorghe Hundorfean, GQ Phan, GY Ku, H Gogas, H Tlaskalova-Hogenova, H. Peter Soyer, HB Wang, Imke Satzger, J Delyon, JA Blansfield, JD Wolchok, JD Wolchok, Jens Ulrich, JJ Nordlund, JM Kirkwood, JS Weber, JS Weber, JS Weber, Julia Vaubel, K Harmankaya, K Sanderson, Katharina C. Kaehler, KD Chmiel, KE Beck, L Min, LM Heinzerling, Lucie M. Heinzerling, Marc Schlaeppi, Michael Fluck, OP Hamnvik, P Attia, PA Prieto, Patrik Weder, Peter Mohr, Ralf Gutzmer, Reinhard Dummer, RH Friedline, Roger von Moos, Rüdiger Hein, S Bhatia, S Wilgenhof, S Wilgenhof, S Wilgenhof, SG Downey, Simone M. Goldinger, SM Liu, Stephan Grabbe, Sylvie Paetzold, T Bakacs, T Matsui, Tabea Wilhelm, Tanja Bergmann, Thomas Eigentler, Ullrich Keller, Uwe Trefzer, WB Breunis, WV Vogel   +88 more
core   +4 more sources