Results 171 to 180 of about 2,772,421 (294)

Acute effects of anti‐seizure medications on network level dynamics: A systematic comparison using multielectrode arrays

Epilepsia, EarlyView.
Abstract Objective A multi‐electrode array (MEA) is a powerful extracellular recording technique for long‐term monitoring of neuronal network activity. In recent years, MEA‐based assays have been applied increasingly to evaluate drug efficacy and neurotoxicity, including the assessment of anti‐seizure medications (ASMs). However, systematic comparisons
Griselda Marku, Lena Gschossmann, Kerstin Hallmann, Heinz Beck, Kunihiko Araki   +4 more
wiley   +1 more source

Translocator protein positron emission tomography as a biomarker for posttraumatic epilepsy and behavioral comorbidities following traumatic brain injury

Epilepsia, EarlyView.
Abstract Objective Traumatic brain injury (TBI) induces widespread and persistent neuroinflammation, which is increasingly recognized as a key contributor to chronic sequelae including posttraumatic epilepsy (PTE), cognitive deficits, and neuropsychiatric disturbances. However, reliable biomarkers for identifying individuals at risk for these long‐term
Mohit Javalgekar, Peravina Thergarajan, Juliana Silva, Emma Braine, Robert Brkljača, Pablo M. Casillas‐Espinosa, Stefanie Dedeurwaerdere, Mohammad Haskali, Usama Kamil, Terence J. O'Brien, Nigel C. Jones, David K. Wright, Bianca Jupp, Lucy Vivash, Idrish Ali   +14 more
wiley   +1 more source

Managing Drug-Resistant Epilepsy and Severe Feeding Difficulties in Miller-Dieker Syndrome: The Role of Enteral Ketogenic Diet. [PDF]

Case Rep Pediatr
Michela P, Matteo P, Pasqua P, Paola R, Silvana G, Monica F.   +5 more
europepmc   +1 more source

Clinical significance of subclinical seizures in epilepsy presurgical evaluation: A systematic review and meta‐analysis

Epilepsia, EarlyView.
Abstract Objective Subclinical seizures (SCSs) remain an understudied aspect of presurgical evaluation in patients with drug‐resistant epilepsy (DRE), with uncertain prevalence, distribution among epilepsy types, and predictive value for surgical outcomes.
Pilar Bosque‐Varela, Panagiota‐Eleni Tsalouchidou, Petra Levicka, Lara Wadi, Elizabeth R. Blackwood, Eugen Trinka, Birgit Frauscher   +6 more
wiley   +1 more source

Intermittent fasting with medium-chain triglycerides in drug-resistant epilepsy: A pilot crossover trial. [PDF]

Epilepsia
Hahn W, Falk E, Balzter A, Foer T, Maierhofer S, Jaumann S, Strehlau S, Möller L, Tsalouchidou PE, Menzler K, Timmermann L, Knake S.   +11 more
europepmc   +1 more source

Pharmaco‐resistant focal epilepsy of undetermined origin responding to corticosteroids: A clinical vignette

Epileptic Disorders, EarlyView.
Félicien Gautier, Patrice H. Lalive, Pierre Mégevand   +2 more
wiley   +1 more source

9.4‐Tesla magnetic resonance imaging in focal epilepsy patients with high‐resolution surface‐based profiling of focal cortical dysplasias

Epilepsia, EarlyView.
Abstract Objective The detection of subtle epileptogenic lesions such as focal cortical dysplasias (FCDs) is a clinical challenge in the management of drug‐resistant focal epilepsy (DRFE). Ultra‐high‐field (UHF) magnetic resonance imaging (MRI) offers increased signal‐to‐noise ratios and spatial resolution compared to 3‐T MRI and may improve diagnostic
Cornelius Kronlage, Pascal Martin, Benjamin Bender, Gisela E. Hagberg, Jonas Bause, Joana R. A. Loureiro, Mathilde Ripart, Sophie Adler, Konrad Wagstyl, Holger Lerche, Niels K. N. Focke, Esther Kuehn   +11 more
wiley   +1 more source

Optimizing Drug-Resistant Epilepsy Management: Cenobamate's role in the Surgery/Neuromodulation Pathway. [PDF]

Drugs R D
Di Gennaro G, Bonanni P, Deleo F, Gambardella A, Michelucci R, Pauletto G, Specchio N, D'Aniello A.   +7 more
europepmc   +1 more source

Perils and progress in epilepsy surgery utilization: Twenty‐five years later

Epilepsia, EarlyView.
Abstract More than 25 years have passed since the first randomized controlled trial (RCT) established that surgery is superior to continued anti‐seizure medication (ASM) for drug‐resistant temporal lobe epilepsy, and nearly as long since a joint practice parameter urged that appropriate surgical candidates be referred to a specialized center for ...
Dario J. Englot
wiley   +1 more source

Deep brain stimulation in pediatric drug-resistant epilepsy: Implications for the developing connectome. [PDF]

Neurotherapeutics
Mithani K, Dinger TF, Gorodetsky C, Ibrahim GM.   +3 more
europepmc   +1 more source