Results 191 to 200 of about 74,202 (303)

Focal cortical dysplasias: modeling pediatric drug-resistant epilepsy using human brain organoids. [PDF]

Front Cell Neurosci
Petralla S, Crocco E, Giustizieri M, De Palma L, Cremisi F, Cherubini E, Specchio N, Cattaneo A, Marinelli S.   +8 more
europepmc   +1 more source

High frequency deep brain stimulation of the hippocampus in a rat model for temporal lobe epilepsy [PDF]

, 2006
Boon, Paul, CLAEYS, P, De Smedt, Tim, Leybaert, Luc, Mabilde, Cyriel, Raedt, Robrecht, Van den broecke, Caroline, Wadman, Wytse, Waterschoot, Liesbeth, Wyckhuys, Tine   +9 more
core   +1 more source

Rhythms in longitudinal thalamic recordings are linked to seizure risk

Epilepsia, EarlyView.
Abstract Objective Seizure unpredictability remains a major clinical challenge for people with epilepsy. Previous works have shown that seizure risk is associated with circadian and multi‐day cycles in both brain and physiological signals. However, it remains unclear whether neural activity from deep brain structures such as the anterior nucleus of the
Xinbing Zhang, Zachary T. Sanger, Thomas Lisko, Steffen Ventz, Robert A. McGovern, Theoden I. Netoff   +5 more
wiley   +1 more source

Clioquinol "<i>Sweetens the Pot</i>" for Drug-Resistant Epilepsy-With an After Taste. [PDF]

Epilepsy Curr
Scharfman HE.
europepmc   +1 more source

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source

Efficacy and safety of adjunctive clobazam in Chinese patients with drug-resistant epilepsy: a single-center real-world study. [PDF]

Front Neurol
Zhang Y, Liu X, Su Z, Xu X, She Y, Chen S, Zhou L.   +6 more
europepmc   +1 more source

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

Epilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin, Alexis Arzimanoglou, Jacqueline French, Kelly G. Knupp, Lieven Lagae, Eugen Trinka, Dennis Dlugos, Emilio Perucca   +7 more
wiley   +1 more source

Locating the epileptogenic zone for drug-resistant epilepsy through neuroelectrophysiological brain network topology. [PDF]

Front Neurosci
Zhang W, Shi Z, Kong W, Gong Y, Lin W, Wu Z, Han Y, Liu Y, Wang T.   +8 more
europepmc   +1 more source

Stiripentol: Unpublished results from the first phase 2 clinical trial in Lennox–Gastaut syndrome conducted in the early 1990s

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to present the results of an exploratory phase 2 trial of stiripentol in Lennox–Gastaut syndrome (LGS). Methods This exploratory single‐blind, single‐arm, nonrandomized sequential‐period phase 2 study was conducted at four centers in France between January 1989 and August 1993.
Stéphane Auvin, Benjamin Serraz, Jérémie Lespinasse, Laurent Chancharme   +3 more
wiley   +1 more source

Real-world outcomes of ketogenic diet therapy in children with drug-resistant epilepsy in a prospective cohort study. [PDF]

Sci Rep
Han R, Xu Y, Sun J, Guo Q, Du K, Dong Y, Li X, Zhang L, Chen H, Li L, Xu D, Duan J, Li B, Zhang X, Zhu C.   +14 more
europepmc   +1 more source