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A structured narrative review on VNS-treated drug-resistant epilepsy: EEG markers, neurochemical mechanisms, and future biomarker-driven computational directions. [PDF]
Front NeurosciMuroni A, Bhat KM, Maleci A, Marrosu F.
europepmc +1 more source
Drug-Resistant Epilepsy and Surgery [PDF]
Current Neuropharmacology, 2017 Epilepsy is a chronic brain disease that is caused by various factors and characterized by recurrent, episodic and temporary central nervous system dysfunction which results due to excessive discharge of brain neurons. In the past decades, despite the continuous development of antiepileptic drugs, there are still many patients with epilepsy progressing
Jiyao Sheng, Shui Liu, Bingjin Li
exaly +3 more sources
Neuromodulation in Drug Resistant Epilepsy [PDF]
Aging and disease, 2021 Epilepsy affects approximately 70 million people worldwide, and it is a significant contributor to the global burden of neurological disorders. Despite the advent of new AEDs, drug resistant-epilepsy continues to affect 30-40% of PWE. Once identified as having drug-resistant epilepsy, these patients should be referred to a comprehensive epilepsy center
Naymee Vélez-Ruiz
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The Lancet Neurology, 2023
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
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Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
openaire +2 more sources
New England Journal of Medicine, 2011
Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Katsuhiro, Kobayashi +2 more
openaire +6 more sources
Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Katsuhiro, Kobayashi +2 more
openaire +6 more sources
Mechanisms of Apoptosis in Drug-Resistant Epilepsy
Neuroscience and Behavioral Physiology, 2022Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune and neurodegenerative processes. Approximately 40% of patients suffer from drug-resistant epilepsy, which leads to an increased risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced ...
E.D. Bazhanova, A.A. Kozlov
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Topiramate for drug-resistant epilepsies
European Journal of Paediatric Neurology, 2000Topiramate is a new anti-epileptic drug with proven efficacy against partial seizures in adults. A retrospective assessment of the use of topiramate in drug-resistant childhood epilepsy was undertaken. Thirty-four children (median age of 10 years; range 2-18 years) were treated for a median of 9 months (range 6-18 months).
S, Yeung +3 more
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Ciprofloxacin for treatment of drug-resistant epilepsy
Epilepsy Research, 2021To investigate the efficacy of short-term treatment with ciprofloxacin in alteration of gut microbiota pattern and reduction of seizure frequency in adult patients with drug-resistant epilepsy.In a prospective study, we investigated the effect of a 5-day course of treatment with ciprofloxacin on gut microbiota pattern and seizure frequency of 23 adults
Hamed Cheraghmakani +7 more
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The Preoperative Evaluation of Drug-Resistant Epilepsy
Pediatric Neurology, 2020Antiepileptic drugs afford good seizure control for approximately 70% of individuals with epilepsy. Epilepsy surgery is extremely helpful for appropriate individuals with drug resistance. Since antiquity, trephination was a crude and invasive technique to manage epilepsy.
Dave F, Clarke +2 more
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Neuroimaging of drug resistance in epilepsy
Current Opinion in Neurology, 2014Drug resistance is an important clinical problem: it is associated with higher rates of somatic and psychiatric comorbidities and cognitive/memory decline, with seizures being just the 'tip of the iceberg'. This review summarizes recent developments in imaging research, focusing specifically on the functional consequence of chronic epilepsies and ...
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