Results 231 to 240 of about 2,772,421 (294)

Characterizing sleep disturbances in developmental and epileptic encephalopathies through natural language processing: A retrospective monocentric study

Epilepsia, EarlyView.
Abstract Objective Sleep disorders are frequent but undercharacterized comorbidities in developmental and epileptic encephalopathies (DEEs). We aimed to estimate the frequency, spectrum, and burden of sleep disturbances across genetic DEE subtypes using real‐world data extracted from electronic health records (EHRs) through natural language processing (
Tommaso Lo Barco, Maxime Douillet, Nicole Chemaly, Audrey Duval, Gianluca D'onofrio, Nicolas Garcelon, Xiaoyi Chen, Rima Nabbout   +7 more
wiley   +1 more source

A first in disease trial of the safety, tolerability, and anti-seizure effects of ES-481 in drug-resistant epilepsy. [PDF]

Epilepsia Open
Foster EC, Millist L, Germaine J, Chamorro S, Roberts C, Nicolo JP, Hosking S, Perucca P, Mullen S, Robinson H, Wharrie R, Walsh B, Reutens D, Irwin K, Zeng H, Niecestro R, O'Brien TJ.   +16 more
europepmc   +1 more source

Ketogenic diet fails to mitigate seizures and neuroinflammatory responses in a mouse model of virus‐induced epilepsy

Epilepsia, EarlyView.
Abstract Objective The ketogenic diet (KD) is a high‐fat, low‐carbohydrate intervention widely used to treat drug‐resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, and microbiota‐dependent mechanisms. Additionally, recent studies suggest that the anticonvulsant effects of KD require the gut microbiota, with ...
Casey H. Meili, Kaitlyn Allen, Daniel J. Doty, Sofia Del Fiol, Ana Beatriz DePaula‐Silva   +4 more
wiley   +1 more source

Multimodal neuroimaging fusion in presurgical evaluation of drug-resistant epilepsy: current evidence, clinical integration, and future directions. [PDF]

Front Neurosci
Zhao Y, Wang M, Shen B, Luo W.
europepmc   +1 more source

Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acidergic (GABAergic) parvalbumin‐positive (PV+) interneurons are critical for maintaining cortical inhibitory tone, with their dysfunction predictably leading to epilepsy. Rapid PV+ interneuron firing is essential for their normal function and is maintained in part by potassium voltage‐gated channels.
Sheryl Anne D. Vermudez, Mustafa Q. Hameed, Yongho Choe, Gabrielle E. McGinty, Amanda M. Liebhardt, Rui Lin, Benjamin Hui, Yini Liang, David J. Arce, Henry H. C. Lee, Mustafa Sahin, Alexander Rotenberg   +11 more
wiley   +1 more source

Beyond seizures: understanding adaptive functioning in drug-resistant epilepsy in patients undergoing palliative surgery. [PDF]

Childs Nerv Syst
Oliveira AVD, Machado HR, Thomé Ú, de Angelis G, Leite JP, Hamad AP, Sakamoto AC, Velasco TR.   +7 more
europepmc   +1 more source

Re‐evaluating impaired consciousness in temporal lobe epilepsy: The role of language dominance and network reorganization

Epilepsia, EarlyView.
Abstract Objective Temporal lobe epilepsy (TLE) frequently affects clinically‐classified ictal consciousness, which the 2025 International League Against Epilepsy (ILAE) classification operationalizes through clinical assessment of awareness and responsiveness.
Radheshyam Stepponat, Marc Berger, Laurin Schäfer, Laura Flamm, Kathrin Kollndorfer, Silvia Bonelli, Gregor Kasprian, Ekaterina Pataraia, Florian Ph. S. Fischmeister   +8 more
wiley   +1 more source

Clinical Characteristics, Treatment Patterns, and Drug-Resistant Epilepsy Among Emirati Adults with Epilepsy. [PDF]

Neurol Ther
Alhammadi M, Alblooshi BK, Ahmed A, Alshaer M, Almazrouei R, Al-Shamsi S.   +5 more
europepmc   +1 more source

Clinical Predictors of Drug-Resistant Epilepsy in Adults: An Analytical Observational Study. [PDF]

Cureus
Sarfraz M, Muzaffar S, Arshad A, Khan A, Jamali AG, Al-Bayati HKW, Taher Khaleefa Khaleefa T, Saeed FB, Esmat Hasan Bazarah M, Khaleefah Al-Fahdawi AT, Intakhab A.   +10 more
europepmc   +1 more source

Hemispherotomy for atypical teratoid rhabdoid tumor-associated drug-resistant epilepsy: illustrative case. [PDF]

J Neurosurg Case Lessons
Hect JL, Ong J, Felker J, Welch W, Greene S, Abel TJ.   +5 more
europepmc   +1 more source