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Update on Cannabidiol in Drug-Resistant Epilepsy
Indian Journal of PediatricsCannabidiol (CBD) has arisen as a promising therapeutic option for children with drug-resistant epilepsy (DRE). CBD has received regulatory nod from different regulatory authorities in the United States, Europe, and India for children with DRE particularly, Dravet syndrome (DS), Lennox Gastaut syndrome (LGS), and Tuberous sclerosis complex (TSC ...
Akanksha Singh +2 more
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Surgical treatment of drug-resistant epilepsy
Burdenko's Journal of NeurosurgeryBackground. Surgical treatment is possible for drug-resistant epilepsy. Localization of epileptogenic zone in temporal lobe or outside it influences the effectiveness of surgical treatment. Objective. To evaluate the effectiveness of surgical treatment of drug-resistant epilepsy. Material and methods.
A.A. Zuev +5 more
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Perampanel: A Review in Drug-Resistant Epilepsy
Drugs, 2015Perampanel (Fycompa®), an orally-active, selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, is a first-in-class antiepileptic drug (AED) offering the convenience of once-daily administration. In the EU and US, perampanel is approved in patients with epilepsy aged ≥12 years for the adjunctive ...
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Animal models of drug‐resistant epilepsy*
Epileptic Disorders, 2012ABSTRACTSeveral animal models are discussed in order to outline features of difficult‐to‐treat or drug‐resistant epilepsy. These models can be categorised as those which show a poor response to different antiepileptic drugs and those in which subgroups of drug‐resistant animals are selected, based on interindividual differences.
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Clinical Management of Drug Resistant Epilepsy: A Review on Current Strategies
Neuropsychiatric Disease and Treatment, 2021Deborah Guery, Sylvain Rheims
exaly
Interneuron Transplantation for Drug-Resistant Epilepsy
Neurosurgery Clinics of North AmericaCurrent epilepsy surgical techniques, such as brain resection, laser ablation, and neurostimulation, target seizure networks macroscopically, and they may yield an unfavorable balance between seizure reduction, procedural invasiveness, and neurologic morbidity.
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