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An integrated peripheral immune circuit of inflammation and dysfunction underlies drug resistance in pediatric drug-resistant epilepsy. [PDF]
J Transl MedZhao T +5 more
europepmc +1 more source
Comprehensive insights into bone health, hormonal patterns, and fracture risks among men with drug resistant epilepsy: a crucial evaluation. [PDF]
Arch Endocrinol MetabPieper C +7 more
europepmc +1 more source
De novo TANC2 stop-loss variant associated with developmental impairment and drug-resistant epilepsy. [PDF]
Epileptic DisordHintermayer MA, Myers KA.
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The Lancet Neurology, 2023
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
openaire +2 more sources
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
openaire +2 more sources
New England Journal of Medicine, 2011
Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Patrick, Kwan +2 more
openaire +6 more sources
Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Patrick, Kwan +2 more
openaire +6 more sources
Mechanisms of Apoptosis in Drug-Resistant Epilepsy
Neuroscience and Behavioral Physiology, 2022Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune and neurodegenerative processes. Approximately 40% of patients suffer from drug-resistant epilepsy, which leads to an increased risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced ...
E.D. Bazhanova, A.A. Kozlov
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Topiramate for drug-resistant epilepsies
European Journal of Paediatric Neurology, 2000Topiramate is a new anti-epileptic drug with proven efficacy against partial seizures in adults. A retrospective assessment of the use of topiramate in drug-resistant childhood epilepsy was undertaken. Thirty-four children (median age of 10 years; range 2-18 years) were treated for a median of 9 months (range 6-18 months).
S, Yeung +3 more
openaire +2 more sources
The Preoperative Evaluation of Drug-Resistant Epilepsy
Pediatric Neurology, 2020Antiepileptic drugs afford good seizure control for approximately 70% of individuals with epilepsy. Epilepsy surgery is extremely helpful for appropriate individuals with drug resistance. Since antiquity, trephination was a crude and invasive technique to manage epilepsy.
Dave F, Clarke +2 more
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Ciprofloxacin for treatment of drug-resistant epilepsy
Epilepsy Research, 2021To investigate the efficacy of short-term treatment with ciprofloxacin in alteration of gut microbiota pattern and reduction of seizure frequency in adult patients with drug-resistant epilepsy.In a prospective study, we investigated the effect of a 5-day course of treatment with ciprofloxacin on gut microbiota pattern and seizure frequency of 23 adults
Hamed Cheraghmakani +7 more
openaire +2 more sources