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The Lancet Neurology, 2023
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
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Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
openaire +2 more sources
Mechanisms of Apoptosis in Drug-Resistant Epilepsy
Neuroscience and Behavioral Physiology, 2022Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune and neurodegenerative processes. Approximately 40% of patients suffer from drug-resistant epilepsy, which leads to an increased risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced ...
E.D. Bazhanova, A.A. Kozlov
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Surgery for Drug-Resistant Epilepsy in Children
New England Journal of Medicine, 2017 Neurosurgical treatment may improve seizures in children and adolescents with drug-resistant epilepsy, but additional data are needed from randomized trials.In this single-center trial, we randomly assigned 116 patients who were 18 years of age or younger with drug-resistant epilepsy to undergo brain surgery appropriate to the underlying cause of ...
Chitra Sarkar, Mani Kalaivani, Ajay Garg
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Ciprofloxacin for treatment of drug-resistant epilepsy
Epilepsy Research, 2021To investigate the efficacy of short-term treatment with ciprofloxacin in alteration of gut microbiota pattern and reduction of seizure frequency in adult patients with drug-resistant epilepsy.In a prospective study, we investigated the effect of a 5-day course of treatment with ciprofloxacin on gut microbiota pattern and seizure frequency of 23 adults
Hamed Cheraghmakani +7 more
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Topiramate for drug-resistant epilepsies
European Journal of Paediatric Neurology, 2000Topiramate is a new anti-epileptic drug with proven efficacy against partial seizures in adults. A retrospective assessment of the use of topiramate in drug-resistant childhood epilepsy was undertaken. Thirty-four children (median age of 10 years; range 2-18 years) were treated for a median of 9 months (range 6-18 months).
S, Yeung +3 more
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Surgery for Drug-Resistant Epilepsy in Children
New England Journal of Medicine, 2018Bertil Rydenhag +2 more
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The Preoperative Evaluation of Drug-Resistant Epilepsy
Pediatric Neurology, 2020Antiepileptic drugs afford good seizure control for approximately 70% of individuals with epilepsy. Epilepsy surgery is extremely helpful for appropriate individuals with drug resistance. Since antiquity, trephination was a crude and invasive technique to manage epilepsy.
Dave F, Clarke +2 more
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Neuroimaging of drug resistance in epilepsy
Current Opinion in Neurology, 2014Drug resistance is an important clinical problem: it is associated with higher rates of somatic and psychiatric comorbidities and cognitive/memory decline, with seizures being just the 'tip of the iceberg'. This review summarizes recent developments in imaging research, focusing specifically on the functional consequence of chronic epilepsies and ...
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Management of Drug-Resistant Epilepsy
Continuum, 2016This review discusses the definition, evaluation, and management of patients with drug-resistant epilepsy.Drug-resistant epilepsy is defined as a failure of two or more appropriately selected and adequately tried anticonvulsant medications to achieve seizure freedom for a sustained period of time in either monotherapy or polytherapy.
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Genetics of drug resistance in epilepsy
Current Neurology and Neuroscience Reports, 2005Drug resistance is a major clinical problem in epilepsy, affecting one in three patients. It is likely to have a complex multifactorial basis, with environmental and genetic contributions. Knowledge of robust genetic factors underlying drug resistance might both improve prediction and permit the development of novel rational treatments for resistance ...
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