Results 261 to 270 of about 2,582,050 (300)

Management of Drug-Resistant Epilepsy

Continuum, 2016
This review discusses the definition, evaluation, and management of patients with drug-resistant epilepsy.Drug-resistant epilepsy is defined as a failure of two or more appropriately selected and adequately tried anticonvulsant medications to achieve seizure freedom for a sustained period of time in either monotherapy or polytherapy.
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Genetics of drug resistance in epilepsy

Current Neurology and Neuroscience Reports, 2005
Drug resistance is a major clinical problem in epilepsy, affecting one in three patients. It is likely to have a complex multifactorial basis, with environmental and genetic contributions. Knowledge of robust genetic factors underlying drug resistance might both improve prediction and permit the development of novel rational treatments for resistance ...
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Neuroimaging of drug resistance in epilepsy

Current Opinion in Neurology, 2014
Drug resistance is an important clinical problem: it is associated with higher rates of somatic and psychiatric comorbidities and cognitive/memory decline, with seizures being just the 'tip of the iceberg'. This review summarizes recent developments in imaging research, focusing specifically on the functional consequence of chronic epilepsies and ...
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Management of Epilepsy in Drug-Resistant Patients

CNS Spectrums, 2010
Epilepsy affects > 2 million people in the United States, making it one of the most common neurobiological conditions. Typically, epilepsy is treated with one of several available antiepileptic drugs and patients are able to experience freedom from seizures with minimal side effects.
Brien J, Smith, Andrew J, Cole
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Connectome biomarkers of drug‐resistant epilepsy

Epilepsia, 2020
AbstractDrug‐resistant epilepsy (DRE) considerably affects patient health, cognition, and well‐being, and disproportionally contributes to the overall burden of epilepsy. The most common DRE syndromes are temporal lobe epilepsy related to mesiotemporal sclerosis and extratemporal epilepsy related to cortical malformations.
Sara Larivière, Andrea Bernasconi, Neda Bernasconi, Boris C. Bernhardt   +3 more
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Focal Cooling for Drug-Resistant Epilepsy

JAMA Neurology, 2022
Epilepsy affects at least 1.2% of the population, with one-third of cases considered to be drug-resistant epilepsy (DRE). For these cases, focal cooling therapy may be a potential avenue for treatment, offering hope to people with DRE for freedom from seizure.
Itamar, Niesvizky-Kogan, Michelle, Bass, Shira R, Goldenholz, Daniel M, Goldenholz   +3 more
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Identification and Treatment of Drug-Resistant Epilepsy

Continuum, 2019
Drug-resistant epilepsy is a potentially life-threatening condition affecting one-third of people living with epilepsy. Despite existing evidence of improved outcomes in patients who received surgical treatment compared to continued medical treatment, epilepsy surgery remains underused in patients with drug-resistant epilepsy.
Ji Yeoun, Yoo, Fedor, Panov
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Neuromodulation in pediatric drug-resistant epilepsy

Epilepsy & Behavior
This is a summary of the three commercially available neuromodulation devices for refractory epilepsy, highlighting their use in children. The article offers a high-level review of the proposed mechanisms of vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation, the pivotal trials leading to their approval for use in the ...
Ann, Hyslop, Marytery, Fajardo
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Surgical treatment of drug-resistant epilepsy

Burdenko's Journal of Neurosurgery
Background. Surgical treatment is possible for drug-resistant epilepsy. Localization of epileptogenic zone in temporal lobe or outside it influences the effectiveness of surgical treatment. Objective. To evaluate the effectiveness of surgical treatment of drug-resistant epilepsy. Material and methods.
A.A. Zuev, N.V. Pedyash, N.P. Utyashev, N.O. Ivin, A.A. Utyasheva, E.A. Gordeeva   +5 more
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Drug resistance in epilepsy: human epilepsy.

Novartis Foundation symposium, 2002
The basis of drug resistance in human epilepsy is not understood. Parallels with resistance in cancer suggest that drug resistance proteins may have a role. To examine this possibility, we have studied human brain tissue containing pathologies capable of causing refractory epilepsy.
S M, Sisodiya, W R, Lint, B N, Harding, M V, Squier, M, Thom   +4 more
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