Results 261 to 270 of about 74,202 (303)
Some of the next articles are maybe not open access.
Topiramate for drug-resistant epilepsies
European Journal of Paediatric Neurology, 2000Topiramate is a new anti-epileptic drug with proven efficacy against partial seizures in adults. A retrospective assessment of the use of topiramate in drug-resistant childhood epilepsy was undertaken. Thirty-four children (median age of 10 years; range 2-18 years) were treated for a median of 9 months (range 6-18 months).
S, Yeung +3 more
openaire +2 more sources
Understanding drug-resistant epilepsy
British Journal of Neuroscience Nursing, 2021Despite the wide choice of antiseizure medications, drug-resistant epilepsy is common. Mark Greener introduces some ways in which researchers are trying to improve outcomes for people with drug-resistant epilepsy.
openaire +1 more source
Mechanisms of Apoptosis in Drug-Resistant Epilepsy
Neuroscience and Behavioral Physiology, 2022Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune and neurodegenerative processes. Approximately 40% of patients suffer from drug-resistant epilepsy, which leads to an increased risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced ...
E.D. Bazhanova, A.A. Kozlov
openaire +2 more sources
Connectome biomarkers of drug‐resistant epilepsy
Epilepsia, 2020AbstractDrug‐resistant epilepsy (DRE) considerably affects patient health, cognition, and well‐being, and disproportionally contributes to the overall burden of epilepsy. The most common DRE syndromes are temporal lobe epilepsy related to mesiotemporal sclerosis and extratemporal epilepsy related to cortical malformations.
Sara Larivière +3 more
openaire +2 more sources
Management of Drug-Resistant Epilepsy
Continuum, 2016This review discusses the definition, evaluation, and management of patients with drug-resistant epilepsy.Drug-resistant epilepsy is defined as a failure of two or more appropriately selected and adequately tried anticonvulsant medications to achieve seizure freedom for a sustained period of time in either monotherapy or polytherapy.
openaire +2 more sources
Genetics of drug resistance in epilepsy
Current Neurology and Neuroscience Reports, 2005Drug resistance is a major clinical problem in epilepsy, affecting one in three patients. It is likely to have a complex multifactorial basis, with environmental and genetic contributions. Knowledge of robust genetic factors underlying drug resistance might both improve prediction and permit the development of novel rational treatments for resistance ...
openaire +2 more sources
Neuroimaging of drug resistance in epilepsy
Current Opinion in Neurology, 2014Drug resistance is an important clinical problem: it is associated with higher rates of somatic and psychiatric comorbidities and cognitive/memory decline, with seizures being just the 'tip of the iceberg'. This review summarizes recent developments in imaging research, focusing specifically on the functional consequence of chronic epilepsies and ...
openaire +2 more sources
Drug resistance in epilepsy: human epilepsy.
Novartis Foundation symposium, 2002The basis of drug resistance in human epilepsy is not understood. Parallels with resistance in cancer suggest that drug resistance proteins may have a role. To examine this possibility, we have studied human brain tissue containing pathologies capable of causing refractory epilepsy.
S M, Sisodiya +4 more
openaire +1 more source
Neuromodulation in pediatric drug-resistant epilepsy
Epilepsy & BehaviorThis is a summary of the three commercially available neuromodulation devices for refractory epilepsy, highlighting their use in children. The article offers a high-level review of the proposed mechanisms of vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation, the pivotal trials leading to their approval for use in the ...
Ann, Hyslop, Marytery, Fajardo
openaire +2 more sources
Animal models of drug‐resistant epilepsy*
Epileptic Disorders, 2012ABSTRACTSeveral animal models are discussed in order to outline features of difficult‐to‐treat or drug‐resistant epilepsy. These models can be categorised as those which show a poor response to different antiepileptic drugs and those in which subgroups of drug‐resistant animals are selected, based on interindividual differences.
openaire +2 more sources